Cocaine duribg adolescence enhances dopamine in response to a natural reinforcer
Cocaine duribg adolescence enhances dopamine in response to a natural reinforcer
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DOI：
10.1016/j.ntt.2006.11.007
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Kirstein, Cheryl L.
中科院分区：
文献类型：
--
作者：
Catlow, Briony J.;Kirstein, Cheryl L.
在青少年发育期间使用可卡因可能会改变受可卡因影响的大脑区域的正常生长，特别是奖励系统，并影响成人的中边缘系统。然而，很少有文献旨在确定动物在青春期是否更容易受到药物的不良影响。本研究调查了青春期或成年期的可卡因预处理是否改变了成年期对自然增强物质的多巴胺能反应。为了评估重复可卡因后中脑边缘系统的反应性，在透析过程中提供蔗糖并收集透析液。无论年龄大小，均经过生理盐水预处理。与基线水平相比，大鼠伏隔核（NAcc）中蔗糖诱导的细胞外多巴胺（DA）水平显着增加。成年后用可卡因预处理的大鼠在添加蔗糖后其 DA 水平也显着增加。有趣的是，与所有其他条件相比，蔗糖摄入显着提高了可卡因预处理的青春期大鼠的 DA 水平。本研究的结果表明，在青春期接受可卡因预处理的大鼠中，暴露于天然增强物质的动物的多巴胺能系统的反应增强。因此，青春期接触可卡因会导致中脑边缘通路的长期功能变化。未来的研究需要确定其在可卡因成瘾中的潜在机制及其潜在作用。 (c) 2006 Elsevier Inc. 保留所有权利。
The use of cocaine during adolescent development could alter the normal growth of brain regions affected by cocaine, specifically the reward system, and impact the adult mesolimbic system. However, there is scant literature aimed at determining whether animals are more vulnerable to the adverse effects of drugs during adolescence. The present study investigated whether cocaine pretreatment in either adolescence or adulthood altered the dopaminergic response to a naturally reinforcing substance in adulthood. To evaluate the responsivity of the mesolimbic system after repeated cocaine, sucrose was offered during the dialysis procedure and dialysates were collected. Regardless of age all saline pretreated. rats had significant increases in sucrose-induced extracellular dopamine (DA) levels in the nucleus accumbens septi (NAcc) as compared to baseline levels. Rats pretreated with cocaine as adults also had significant increases in DA levels after sucrose. Interestingly, sucrose intake significantly enhanced DA levels in cocaine pretreated adolescent rats as compared to all other conditions. The results from the present study show that in rats pretreated with cocaine during adolescence there is an enhanced response of the dopaminergic system in animals exposed to a naturally reinforcing substance. Therefore, cocaine exposure during adolescence results in long-term functional changes in the mesolimbic pathway. Future studies need to ascertain the underlying mechanisms and their potential role in cocaine addiction. (c) 2006 Elsevier Inc. All rights reserved.