Methylmercury: a potential environmental risk factor contributing to epileptogenesis.
Methylmercury: a potential environmental risk factor contributing to epileptogenesis.
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DOI：
10.1016/j.neuro.2011.12.014
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发表时间：
2012-01
期刊：
影响因子：
3.4
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Yuan Y
癫痫或癫痫障碍是人类最常见的神经系统疾病之一。尽管离子通道和受体的基因突变以及脑损伤等其他危险因素与癫痫的发生有关，但大多数癫痫病例的潜在原因仍不清楚。基因-环境相互作用被认为在癫痫的病因中起着关键作用。接触环境化学品是一个重要的风险因素。甲基汞是一种重要的环境神经毒物，主要针对中枢神经系统(CNS)。急性或慢性甲基汞中毒的患者或动物通常表现为癫痫发作或表现出对癫痫发作的易感性增加，这表明接触甲基汞可能与癫痫的发生有关。这篇简短的综述强调了甲基汞暴露，特别是发育性暴露对人类和动物癫痫易感性的影响，并讨论了低水平甲基汞暴露在癫痫发生中的潜在作用。该综述还提出，甲基汞对抑制性GABA能系统的优先作用，导致兴奋性谷氨酸能功能的解除抑制，可能是甲基汞引起癫痫敏感性改变的潜在机制之一。
Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although genetic mutations in ion channels and receptors and some other risk factors such as brain injury are linked to epileptogenesis, the underlying cause for the majority of epilepsy cases remains unknown. Gene-environment interactions are thought to play a critical role in the etiology of epilepsy. Exposure to environmental chemicals is an important risk factor. Methylmercury (MeHg) is a prominent environmental neurotoxicant, which targets primarily the central nervous system (CNS). Patients or animals with acute or chronic MeHg poisoning often display epileptic seizures or show increased susceptibility to seizures, suggesting that MeHg exposure may be associated with epileptogenesis. This mini-review highlights the effects of MeHg exposure, especially developmental exposure, on the susceptibility of humans and animals to seizures, and discusses the potential role of low level MeHg exposure in epileptogenesis. This review also proposes that a preferential effect of MeHg on the inhibitory GABAergic system, leading to disinhibition of excitatory glutamatergic function, may be one of the potential mechanisms underlying MeHg-induced changes in seizure susceptibility.
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影响因子：
8.3
作者：
Axtell, CD;Cox, C;Clarkson, TW
通讯作者：
Clarkson, TW
影响因子：
3.4
作者：
Allen, JW;Shanker, G;Aschner, M
通讯作者：
Aschner, M
影响因子：
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作者：
BRENNER, RP;SNYDER, RD
通讯作者：
SNYDER, RD
影响因子：
8.3
作者：
Cordier, S;Garel, M;Amiel-Tison, C
通讯作者：
Amiel-Tison, C
DOI：
10.1016/j.cbpc.2010.01.001
发表时间：
2010-04-01
影响因子：
3.9
作者：
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通讯作者：
Chan, Laurie H. M.