Peer Social Environment Impacts Behavior and Dopamine D1 Receptor Density in Prairie Voles (Microtus ochrogaster)
Peer Social Environment Impacts Behavior and Dopamine D1 Receptor Density in Prairie Voles (Microtus ochrogaster)
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DOI：
10.1016/j.neuroscience.2023.02.002
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发表时间：
2023-02-26
期刊：
影响因子：
3.3
通讯作者：
Beery, Annaliese K.
中科院分区：
文献类型：
--
作者：
Lee, Nicole S.;Kim, Claire Y.;Beery, Annaliese K.
田鼠（Microtus ochrogaster）是社会性的一夫一妻制啮齿动物，与配偶和同性同伴形成选择性的、持久的关系。目前还不清楚在何种程度上支持“同伴关系”的机制与参与配偶关系的机制相似。配对键的形成依赖于多巴胺神经传递，而同伴关系的形成则不依赖于多巴胺神经传递，这为关系类型特异性提供了证据。目前的研究评估了不同社会环境中雄性和雌性田鼠多巴胺D1受体密度的内源性结构变化，包括长期同性伴侣关系，新的同性伴侣关系，社会隔离和群体住房。我们还将多巴胺D1受体密度和社会环境与社交互动和伴侣偏好测试中的行为联系起来。与先前的研究结果在配偶对，田鼠配对新的同性伴侣并没有表现出上调D1结合在核神经节（NAcc）相对于对照配对断奶。这与关系类型的差异是一致的：配对关系中的D1上调有助于通过选择性攻击来维持排他性关系，我们发现新的同伴关系的形成并没有增强攻击性。隔离导致NAcc D1结合增加，即使在社会圈养的田鼠中，具有较高D1结合的个体也表现出增加的社会回避。这些研究结果表明，D1结合的升高可能是亲社会性降低的原因和后果。这些结果突出了不同的非生殖社会环境的神经和行为后果，并有助于越来越多的证据表明，生殖和非生殖关系形成的机制是不同的。阐明后者是必要的，以了解机制背后的社会行为超越交配的背景。(c)2023年，任作家。由Elsevier Ltd代表IBRO出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
voles (Microtus ochrogaster) are socially monogamous rodents that form selective, long-lasting relationships with mates and with same-sex peers. It is unknown to what extent mechanisms supporting 'peer relationships' are similar to those involved in mate relationships. The formation of pair bonds is dependent on dopamine neurotransmission, whereas the formation of peer relationships is not, providing evidence of relation- ship type-specificity. The current study assessed endogenous structural changes in dopamine D1 receptor den- sity in male and female voles across different social environments, including long-term same-sex partnerships, new same-sex partnerships, social isolation, and group housing. We also related dopamine D1 receptor density and social environment to behavior in social interaction and partner preference tests. Unlike prior findings in mate pairs, voles paired with new same-sex partners did not exhibit upregulated D1 binding in the nucleus accumbens (NAcc) relative to controls paired from weaning. This is consistent with differences in relationship type: D1 upreg- ulation in pair bonds aids in maintaining exclusive relationships through selective aggression, and we found that formation of new peer relationships did not enhance aggression. Isolation led to increases in NAcc D1 binding, and even across socially housed voles, individuals with higher D1 binding exhibited increased social avoidance. These findings suggest that elevated D1 binding may be both a cause and a consequence of reduced prosociality. These results highlight the neural and behavioral consequences of different non-reproductive social environ- ments and contribute to growing evidence that the mechanisms underlying reproductive and non-reproductive relationship formation are distinct. Elucidation of the latter is necessary to understand mechanisms underlying social behavior beyond a mating context.(c) 2023 The Authors. Published by Elsevier Ltd on behalf of IBRO. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).