Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse T3 and the QT interval during long-term amiodarone treatment.
Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse T3 and the QT interval during long-term amiodarone treatment.
复制标题
胺碘酮长期治疗期间血清胺碘酮、去乙基胺碘酮、逆转 T3 水平和 QT 间期之间的相互关系。
DOI：
10.1016/0002-8703(86)90092-x
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发表时间：
1986
影响因子：
4.8
通讯作者：
Fred Morady
中科院分区：
文献类型：
--
作者：
J. Baerman;T. M. Annesley;Lorenzo A. DiCarlo;Mary Kay Foley;John M. Nicklas;Barry J. Crevey;Fred Morady
对22例长期使用胺碘酮治疗的患者进行了血清胺碘酮、去乙基胺碘酮、逆T3水平与校正QT间期变化（ΔQTc）之间的相互关系的研究。随访1、3、6个月时，血清胺碘酮或去乙基胺碘酮水平与t31逆转之间的相关系数为0.01 ~ - 0.2 （p < 0.4）。在同一时间间隔内，胺碘酮和去乙基胺碘酮水平与ΔQTcranged的相关系数为0.1 ~−0.1 (p> 0.6)，逆t3与ΔQTcalso的相关系数为0.1 ~−0.1 （p> 0.5）。代入百分比ΔQTcfor ΔQTcalso并没有显示出显著的相关性。这些数据表明，在监测接受胺碘酮治疗的患者时，血清逆转t3水平不能代替血清胺碘酮水平。血清逆转t3水平与ΔQTcsuggests之间缺乏相关性，表明胺碘酮治疗期间发生的复极延迟不是继发于胺碘酮诱导的甲状腺激素代谢异常。
The interrelationships between serum levels of amiodarone, desethylamiodarone, and reverse T3, and changes in the corrected QT interval (ΔQTc) were examined in 22 patients during long-term treatment with amiodarone. At 1, 3, and 6 months of follow-up, the correlation coefficient between serum levels of amiodarone or desethylamiodarone and reverse T3ranged from 0.01 to −0.2 (p> 0.4). At the same time intervals, the correlation coefficient between both amiodarone and desethylamiodarone levels and ΔQTcranged from 0.1 to −0.1 (p> 0.6), and the correlation coefficient between reverse T3and ΔQTcalso ranged between 0.1 to −0.1 (p> 0.5). Substituting percent ΔQTcfor ΔQTcalso did not reveal a significant correlation. These data demonstrate that serum levels of reverse T3cannot be used as a substitute for serum levels of amiodarone in monitoring patients being treated with amiodarone. The absence of a correlation between serum reverse T3levels and ΔQTcsuggests that the delay in repolarization which occurs during amiodarone therapy is not secondary to an amiodarone-induced abnormality in thyroid hormone metabolism.