Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: The Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010
Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: The Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010
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DOI：
10.1507/endoc
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发表时间：
2014-01-01
影响因子：
2
通讯作者：
Moon, Seong-Su
中科院分区：
文献类型：
--
作者：
Moon, Seong-Su
肌肉减少症是代谢紊乱的一个新出现的危险因素。目前还没有关于肌肉减少症与胰岛素抵抗、糖尿病和代谢综合征（MS）相关性的研究报告，这些研究是根据年龄组和一般人群的肥胖状况进行的。我们调查了这些协会在韩国人口。参与者包括4558名男性和5874名女性，他们来自第四次和第五次韩国国民健康和营养检查调查（2009年和2010年），年龄≥ 20岁或以上。年龄分为三组（20-39岁、40-59岁和≥ 60岁）。根据体重指数定义肥胖。肌肉减少症定义为年轻成人的无脊椎骨骼肌质量（ASM）除以体重（Wt）（%），低于性别特异性平均值> 2SD。计算胰岛素抵抗的稳态模型评估（HOMA-IR）。在调整混杂变量后，非肥胖组的肌肉减少症与HOMA-IR显著相关（P
Sarcopenia is an emerging risk factor for metabolic disorders. No study of the association of sarcopenia with insulin resistance, diabetes, and metabolic syndrome (MS) according to age group and obesity status in the general population has been reported. We investigated these associations in the Korean population. Participants included 4558 males and 5874 females, who were >= 20 years of age or older from the fourth and fifth Korea National Health and Nutritional Examination Surveys of the Korean population (2009 and 2010). Age was categorized according to three groups (20-39, 40-59, and >= 60 years). Obesity was defined according to body mass index. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (Wt) (%) of > 2SD below the sex-specific mean for young adults. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. After adjustment for confounding variables, sarcopenia showed a significant association with HOMA-IR in the non-obese group (P