Osteoprogenitors and the hematopoietic microenvironment
Osteoprogenitors and the hematopoietic microenvironment
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DOI：
10.1016/j.beha.2011.01.005
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发表时间：
2011-03-01
影响因子：
2.1
通讯作者：
Riminucci, Mara
中科院分区：
文献类型：
--
作者：
Bianco, Paolo;Sacchetti, Benedetto;Riminucci, Mara
通过解剖学和表型（表达CD 146的外膜网状细胞）鉴定人骨髓中的骨骼祖细胞（所谓的间充质干细胞）与认识到转移造血微环境的能力是骨骼祖细胞的固有特性相一致。由于这些细胞产生成骨细胞，与窦状隙（它们动态地引导窦状隙的组装）相关联，并且与基质网状细胞一致并自我更新为基质网状细胞，这些细胞是造血微环境的关键组织者。它们作为成骨细胞和窦状隙位置的性质调和了骨内膜表面和窦状隙壁作为造血干细胞“小生境”的双重观点，并突出了小生境/微环境的动态性质，该小生境/微环境基本上由具有骨骼组织祖细胞/干细胞性质的细胞维持。这一观点将长期公认的，有点神秘的，骨和骨髓之间的相互作用带入了一个新的视角，两个干细胞在同一个生态位相互作用。(C)2011年由Elsevier Ltd.出版
The identification of skeletal progenitor cells in the human bone marrow (so-called mesenchymal stem cells) by anatomy and phenotype (CD146-expressing, adventitial reticular cells) has coincided with the recognition that the ability to transfer the hematopoietic microenvironment is an inherent property of skeletal progenitor cells. Inasmuch as these cells generate osteoblasts, associate with sinusoids (the assembly of which they dynamically direct), and coincide with, and self-renew into, stromal reticular cells, these cells are pivotal organizers of the hematopoietic microenvironment. Their nature as osteogenic cells and sinusoidal location reconcile the dual view of endosteal surfaces and sinusoidal walls as the hematopoietic stem cell "niches", and highlight the dynamic nature of a niche/microenvironment essentially maintained by cells with properties of progenitors/stein cells for skeletal tissues. This view brings the long recognized, and somewhat mysterious, interaction between bone and bone marrow into a new perspective, where two stem cells interact with each other at the same niche. (C) 2011 Published by Elsevier Ltd.