Frequency power and coherence of electroencephalography are correlated with the severity of Alzheimer's disease: A multicenter analysis in Taiwan
Frequency power and coherence of electroencephalography are correlated with the severity of Alzheimer's disease: A multicenter analysis in Taiwan
复制标题
DOI：
10.1016/j.jfma.2013.07.008
复制
发表时间：
2015-08-01
影响因子：
3.2
通讯作者：
Lee, Tsung-Chieh
中科院分区：
文献类型：
--
作者：
Chen, Chih-Chung;Hsu, Chien-Yeh;Lee, Tsung-Chieh
背景/目的：阿尔茨海默病(AD)患者平均脑电(EEG)频率减慢已有定论，但EEG改变是否能反映AD的严重程度尚不确定。我们试图建立定量的脑电参数，以便在临床实践中评估AD。方法：选择来自4个神经科机构的95例新诊断的不同阶段的AD患者作为研究对象。采集标准头皮静息脑电数据进行定量分析。结果：晚期阿尔茨海默病患者的慢-快波功率比较大。在几个功率比参数中，总体功率比、增量与α频段功率比和β频段功率比与AD分期的相关性最好(P<；0.05)。晚期阿尔茨海默病患者多个脑区的一致性降低。这一现象在中央顶叶区域最为明显(P<；0.05在任意两个患者组之间)。结论：AD患者整体慢速功率比增加和中央顶叶半球间α带一致性降低与疾病进展密切相关。这两个定量脑电参数可能有助于在日常临床实践中评估AD患者。阿尔茨海默病患者的整体功率比改变可能提示主导频率的改变，而大脑半球间α频段一致性降低可能提示功能性连接中断和胼胝体异常。版权所有(C)2013，爱思唯尔台湾有限责任公司及台湾医学会。版权所有。
Background/Purpose: Slowing of average electroencephalography (EEG) frequency in Alzheimer's disease (AD) is well established, but whether EEG changes are able to reflect the severity of AD is uncertain. We attempt to establish quantitative EEG parameters that are suitable for evaluating AD in clinical practice.Methods: Ninety-five patients with newly diagnosed AD at different stages from four neurologic institutes were enrolled for the study. Standard scalp resting EEG data were collected for quantitative analysis. Global band power ratio and interhemispheric alpha band coherence were calculated.Results: Patients with advanced AD had a greater slow-to-fast wave power ratio. Among several power ratio parameters, global theta and delta to alpha and beta band power ratio showed the best correlation with stages of AD (p < 0.05 between any two patient groups). Patients with advanced AD had decreased coherence in multiple brain regions. The phenomenon was most prominent in the centroparietal region (p < 0.05 between any two patient groups).Conclusion: Increased global slow-to-fast power ratio and decreased centroparietal interhemispheric alpha band coherence are strongly correlated with disease progress in AD patients. These two quantitative EEG parameters may help evaluate AD patients in daily clinical practice. Global power ratio changes may suggest a shift of dominant frequency, and decreased interhemispheric alpha band coherence may suggest functional disconnection and corpus callosum abnormalities in AD patients. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.