Association between cigarette smoking, white blood cell count, and metabolic syndrome as defined by the Japanese criteria
Association between cigarette smoking, white blood cell count, and metabolic syndrome as defined by the Japanese criteria
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DOI：
10.2169/internalmedicine.46.0136
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发表时间：
2007-01-01
影响因子：
1.2
通讯作者：
Yamakado, Minoru
中科院分区：
文献类型：
--
作者：
Ishizaka, Nobukazu;Ishizaka, Yuko;Yamakado, Minoru
目的吸烟增加循环白色血细胞（WBC）计数和代谢综合征的患病率。我们调查了吸烟、白细胞计数和日本标准定义的代谢综合征之间的关系。方法对2005 ~ 2006年3 687例男性普查资料进行分析。结果校正年龄和总胆固醇后，既往吸烟和当前吸烟与最高WBC四分位数（6.3 × 103细胞/μ L）相关，比值比分别为1.35（95%CI 1.09-1.66，P= 0.0055）和4.45（95%CI 3.69-5.37，P < 0.0001）。结果发现，白细胞计数增加是代谢综合征的危险因素;另一方面，当单独分析每个白细胞计数四分位数时，未发现当前吸烟是代谢综合征的预测因子。结论：我们的数据表明，MetS的风险，定义为日本标准，可能是由白细胞计数在日本男性，无论他们的吸烟状况，虽然它也应该注意到，吸烟增加循环白细胞计数的数量。
Objective Cigarette smoking increases the circulating white blood cell (WBC) count and the prevalence of metabolic syndrome. We investigated the association between cigarette smoking, WBC count, and metabolic syndrome as defined by the Japanese criteria. Method Cross-sectional data from 3,687 men undergoing general health screening between 2005 and 2006 were analyzed. Results After adjustment for age and total cholesterol, former and current smoking were associated with the highest WBC quartile (6.3 x 10(3) cells/mu L) with an odds ratio of 1.35 (95% CI 1.09-1.66, P= 0.0055) and 4.45 ( 95% CI 3.69-5.37, P < 0.0001), respectively. It was found that increased WBC count was a risk factor for metabolic syndrome; on the other hand, the current smoking was not found to be a predictor for metabolic syndrome, when each WBC count quartile was separately analyzed. Conclusions Our data suggest that the risk for MetS, defined by Japanese criteria, might be estimated by the WBC count in Japanese men irrespective of their smoking status, although it should also be noted that the cigarette smoking increases the number of circulating WBC count.