Effect of renal nerve stimulation on NaCl and H2O transport in Henle's loop of the rat.
Effect of renal nerve stimulation on NaCl and H2O transport in Henle's loop of the rat.
复制标题
肾神经刺激对大鼠亨利氏襻中 NaCl 和 H2O 转运的影响。
DOI：
10.1152/ajprenal.1982.243.6.f576
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Sawin,LL
中科院分区：
文献类型：
--
作者：
DiBona,GF;Sawin,LL
为了评估肾神经刺激对Henle环内钠、氯和水运输的影响，采用肾清除率和Henle环微灌注技术（近端曲小管灌注部位，远端曲小管早期收集部位）对麻醉的等渗盐水大鼠进行实验。与对照组相比，低频（小于1.0 Hz）肾神经刺激降低了绝对尿流率和部分尿流率以及钠和氯化物排泄，但不影响平均动脉压、肾小球滤过率、肾血流量或肾血管阻力。在Henle环中，水的吸收运输不受影响，而在低频刺激肾神经时，低水（Na 111 +/- 49 peq/min）和等渗盐水体积扩张大鼠（Na 154 +/- 69 peq/min, Cl 180 +/- 52 peq/min）的钠和氯的吸收运输均增加。低频肾神经刺激通过增加肾小管钠和氯的重吸收的直接作用减少尿钠和氯的排泄。除了增加近端小管钠重吸收的既定作用外，Henle’s loop钠和氯化物吸收也增加，支持这些结构的肾上腺素能神经支配的生理作用。
To assess the effect of renal nerve stimulation on sodium, chloride, and water transport in the loop of Henle, experiments were performed in anesthetized hydropenic and isotonic saline volume-expanded rats using renal clearance and Henle's loop microperfusion techniques (end-proximal convoluted tubule perfusion site, early distal convoluted tubule collection site). As compared with the control period values, low-frequency (less than 1.0 Hz) renal nerve stimulation decreased absolute and fractional urinary flow rate and sodium and chloride excretion without affecting mean arterial pressure, glomerular filtration rate, renal blood flow, or renal vascular resistance. In the loop of Henle, the absorptive transport of water was not affected, whereas the absorptive transport of sodium and chloride was increased in both hydropenic (Na 111 +/- 49 peq/min) and isotonic saline volume-expanded rats (Na 154 +/- 69 peq/min, Cl 180 +/- 52 peq/min) during low-frequency renal nerve stimulation. Low-frequency renal nerve stimulation decreases urinary sodium and chloride excretion via a direct effect of increasing renal tubular sodium and chloride reabsorption. In addition to the established effect of increasing proximal tubular sodium reabsorption, Henle's loop sodium and chloride absorption are also increased, supporting a physiological role for the adrenergic innervation of these structures.