Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting
Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting
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DOI：
10.1016/j.cell.2019.08.040
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发表时间：
2019-10-03
期刊：
影响因子：
64.5
通讯作者：
Ganguly, Karunesh
中科院分区：
文献类型：
--
作者：
Kim, Jaekyung;Gulati, Tanuj;Ganguly, Karunesh
睡眠与记忆的巩固和记忆的遗忘都有关系。然而，目前还不清楚是什么控制着巩固和遗忘之间的平衡。在这里，我们测试了睡眠期间活动依赖性处理如何差异调节这两个过程。我们特别研究了非快速眼动（NREM）睡眠期间的神经再激活与神经修复技能的神经相关性的巩固与减弱之间的因果关系。引人注目的是，我们发现慢振荡（SO）和δ（δ）波在巩固与遗忘中具有可分离和竞争的作用。通过使用闭环光遗传学方法调节与SO或δ波相关的皮层尖峰，我们可以分别削弱或加强巩固，从而双向调节睡眠依赖性性能增益。我们进一步发现，在时间耦合的纺锤体SO相对于δ波的变化可以解释这种影响。因此，我们的研究结果表明，由SO和δ波驱动的神经活动在睡眠依赖的记忆巩固中具有竞争作用。
Sleep has been implicated in both memory consolidation and forgetting of experiences. However, it is unclear what governs the balance between consolidation and forgetting. Here, we tested how activity-dependent processing during sleep might differentially regulate these two processes. We specifically examined how neural reactivations during non-rapid eye movement (NREM) sleep were causally linked to consolidation versus weakening of the neural correlates of neuroprosthetic skill. Strikingly, we found that slow oscillations (SOs) and delta (delta) waves have dissociable and competing roles in consolidation versus forgetting. By modulating cortical spiking linked to SOs or delta waves using closed-loop optogenetic methods, we could, respectively, weaken or strengthen consolidation and thereby bidirectionally modulate sleep-dependent performance gains. We further found that changes in the temporal coupling of spindles to SOs relative to delta waves could account for such effects. Thus, our results indicate that neural activity driven by SOs and delta waves have competing roles in sleep-dependent memory consolidation.