Merkel cell carcinoma can be indolent: A case with 7 locoregional recurrences over 15 years highlights the importance of patient-tailored management.
Merkel cell carcinoma can be indolent: A case with 7 locoregional recurrences over 15 years highlights the importance of patient-tailored management.
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DOI：
10.1016/j.jdcr.2021.08.009
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发表时间：
2021-10
影响因子：
--
通讯作者：
Nghiem P
中科院分区：
文献类型：
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作者：
Breneman A;Akaike T;Paulson KG;Breneman DL;Nghiem P
默克尔细胞癌(MCC)是一种罕见的侵袭性神经内分泌皮肤恶性肿瘤。1复发或转移的患者通常预后较差，通常采取积极的治疗措施。1我们报告一例无痛、异常长病程的MCC患者，病程超过15年，在发生远处转移之前有7次局部复发。因为他在基线时有四种主要的合并症，所以选择了不那么激进的治疗方法来治疗他的复发，在他15年的病程中，绝大多数时间都没有疾病的证据。
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy. 1 Patients who develop recurrences or metastases usually have poor prognoses and are often treated aggressively. 1 We report a case of a man with an indolent, unusually long course of MCC over 15 years with 7 locoregional recurrences before developing distant metastases. Because he had 4 major comorbidities at baseline, less aggressive therapies were chosen for his recurrences, and there was no evidence of disease for the vast majority of his 15-year course.