Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction
Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction
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DOI：
10.1530/joe-13-0302
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发表时间：
2013-12-01
影响因子：
4
通讯作者：
Ahmed, R. G.
中科院分区：
文献类型：
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作者：
Ahmed, R. G.
多氯联苯（PCBs）是一种持久性环境污染物，可严重干扰内分泌系统。在本研究中，对早期断奶的雄性大鼠连续两天（出生后第15和16天）单次腹腔注射2，3，6 - 2 '，5'-五氯联苯（PCB 95; 32 mg/kg/天），并在最后一次给药后24和48 h处死。与对照组相比，PCB 95处理组的细胞凋亡率明显降低（P
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that can severely disrupt the endocrine system. In the present study, early-weanedmale rats were administered a single dose of 2,3,6-2',5'-pentachlorinated biphenyl (PCB 95; 32 mg/kg per day, by i.p. injection) for two consecutive days (postnatal days (PNDs) 15 and 16) and killed 24 and 48 h after the administration of the last dose. Compared with the control group, administration of PCB 95 induced a reduction (P