Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking
Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking
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Mu阿片受体基因（OPRM1）调节父母注意力对社会支持寻求的影响
DOI：
10.1007/s40750-022-00192-w
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发表时间：
2022
影响因子：
1.6
通讯作者：
Ohtsubo Yohsuke
中科院分区：
文献类型：
--
作者：
Zheng Shaofeng;Ishii Keiko;Masuda Takahiko;Matsunaga Masahiro;Noguchi Yasuki;Yamasue Hidenori;Ohtsubo Yohsuke
众所周知，关心、敏感的养育方式与儿童和青少年寻求支持行为的参与程度较高有关。然而，还没有研究探讨了感知父母的关注在成年早期寻求社会支持中的作用。越来越多的证据表明，μ-阿片受体基因多态性（OPRM 1A 118 G）调节了一个人对社会环境的反应。由差异易感性理论的基因-环境相互作用，本研究探讨是否theOPRM 1多态性将缓和感知父母的注意力和社会支持寻求在成年早期之间的关联。MethodsSixhundred和20名日本本科生自我报告的关注量，他们主观认为他们的父母给他们在童年和完成量表，评估寻求支持的行为。结果父母关注感与OPRM 1基因型对社会支持寻求的交互作用显著。具体而言，感知父母的关注只有显着和积极的预测OPRM 1GG载体的社会支持寻求响应stress.ConclusionsThe研究结果支持的观点，即OPRM 1多态性调节早期经验和发展成果之间的关联。
ObjectiveCaring, sensitive parenting is known to be associated with higher levels of engagement in support-seeking behaviors among children and young adolescents. However, no study has yet explored the role of perceived parental attention in social support seeking in early adulthood. Growing evidence suggests that the µ-opioid receptor gene polymorphism (OPRM1A118G) moderates one’s responsiveness to social environments. Prompted by the differential susceptibility theory of gene–environment interaction, the present study examined whether theOPRM1polymorphism would moderate the association between perceived parental attention and social support seeking in early adulthood.MethodsSix hundred and twenty Japanese undergraduate students self-reported the amount of attention they subjectively perceived their parents to have given them during childhood and completed scales that assess support-seeking behaviors. Clippings of their fingernails were collected for genotyping.ResultsThe results showed that the interactive effect of perceived parental attention andOPRM1genotypes on social support seeking was significant. Specifically, perceived parental attention only significantly and positively predictedOPRM1GG carriers’ social support seeking in response to stress.ConclusionsThe findings support the view thatOPRM1polymorphism moderates the association between early experiences and developmental outcomes.