The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function
The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function
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DOI：
10.1249/mss.0b013e31802f04c7
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发表时间：
2007-04-01
期刊：
影响因子：
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通讯作者：
Shen, Chwan-Li
中科院分区：
文献类型：
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作者：
Ferris, Lee T.;Williams, James S.;Shen, Chwan-Li
脑源性神经营养因子（Brain-derived neurotrophic factor，BDNF）是神经营养因子家族中的一员，参与神经元的传递、调节和可塑性。以前的动物研究已经证明，急性和慢性运动会导致不同大脑区域的BDNF增加。目的：确定急性运动对人类血清BDNF水平的影响，并确定运动强度与BDNF反应之间的关系。此外，研究了BDNF变化与认知功能之间的关系。研究方法：15名受试者（25.4 ± 1.01岁; 11名男性，4名女性）进行了分级运动试验（GXT），用于在踏车功率计上测定最大摄氧量（VO 2 max）和运动阈值（V-Th）。在不同的日子里，随后进行了两次30分钟的耐力赛，分别在低于V-Th 20%（V-Th - 20）和高于V-Th 10%（V-Th + 10）的情况下进行。血清BDNF和认知功能测定之前和之后的GXT和耐力赛与酶联免疫吸附试验（ELISA）和Stroop测试，分别。结果：平均VO（2 max）为2805.8 +/- 164.3 mL（.）min（-1）（104.2 +/- 7.0%预测值）。BDNF值（pg（.）在V-Th + 10（13%）和GXT（30%）运动后，与基线相比增加（P < 0.05）。在V-Th - 20之后，BDNF与基线相比没有显著变化。脑源性神经营养因子的变化与最大摄氧量无相关性，但与乳酸的变化有相关性（r = 0.57; P < 0.05）。在所有运动条件下，认知功能评分都有所改善，但它们与BDNF的变化无关。结论：运动后人体BDNF水平显著升高，且升高幅度与运动强度有关。鉴于BDNF可以双向通过血脑屏障，强度依赖性的发现可能有助于设计维持或改善神经健康的运动处方。
Brain-derived neurotrophic factor (BDNF) is one of a family of neurotrophic factors that participates in neuronal transmission, modulation and plasticity. Previous studies using animals have demonstrated that acute and chronic exercise leads to increases in BDNF in various brain regions. Purpose: To determine the effects of acute exercise on serum BDNF levels in humans, and to determine the relationship between exercise intensity and BDNF responses. Additionally, the relationship between changes in BDNF and cognitive function was examined. Methods: Fifteen subjects (25.4 +/- 1.01 yr; 11 male, 4 female) performed a graded exercise test (GXT) for the determination Of VO2max and ventilatory threshold (V-Th) on a cycle ergometer. On separate days, two subsequent 30-min endurance rides were performed at 20% below the V-Th (V-Th - 20) and at 10% above the V-Th (V-Th + 10). Serum BDNF and cognitive function were determined before and after the GXT and endurance rides with an enzyme-linked immunosorbent assay (ELISA) and the Stroop tests, respectively. Results: The mean VO(2max)was 2805.8 +/- 164.3 mL(.)min(-1) (104.2 +/- 7.0% pred). BDNF values (pg(.)mL(-1)) increased from baseline (P < 0.05) after exercise at the V-Th + 10 (13%) and the GXT (30%). There was no significant change in BDNF from baseline after the V-Th - 20. Changes in BDNF did not correlate with VO2max during the GXT, but they did correlate with changes in lactate (r = 0.57; P < 0.05). Cognitive function scores improved after all exercise conditions, but they did not correlate with BDNF changes. Conclusion: BDNF levels in humans are significantly elevated in response to exercise, and the magnitude of increase is exercise intensity dependent. Given that BDNF can transit the blood-brain barrier in both directions, the intensity-dependent findings may aid in designing exercise prescriptions for maintaining or improving neurological health.