Disseminated herpes simplex infection with retinitis in a renal allograft recipient.
Disseminated herpes simplex infection with retinitis in a renal allograft recipient.
复制标题
同种异体肾移植受者的播散性单纯疱疹感染伴视网膜炎。
DOI：
10.1016/s0161-6420(83)34589-9
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发表时间：
1983
期刊：
影响因子：
13.7
通讯作者：
S. Naraqi
中科院分区：
文献类型：
--
作者：
E. Uninsky;L. Jampol;S. Kaufman;S. Naraqi
1例免疫抑制的同种异体肾移植受者发生双侧坏死性视网膜炎。临床表现、血清学和病毒培养研究证实了播散性单纯疱疹病毒感染。巨细胞病毒培养和血清学试验均为阴性。这些证据有力地支持了单纯疱疹病毒性视网膜炎的诊断。逐渐减少免疫抑制药物和给予阿糖腺苷似乎暂时阻止了一只眼睛的疾病进展，并导致另一只眼睛的视网膜炎愈合。在患者死于脑膜脑炎之前，受累更严重的右眼随后的进展导致渗出性视网膜脱离和视力丧失。免疫抑制患者坏死性视网膜炎的鉴别诊断必须考虑单纯疱疹病毒性视网膜炎。
An immunosuppressed recipient of a renal allograft developed bilateral necrotizing retinitis. Disseminated herpes simplex infection was documented by clinical findings and serologic and viral culture studies. Cultures and serologic tests for cytomegalovirus were negative. The evidence strongly favored the diagnosis of herpes simplex retinitis. Tapering of immunosuppressive drugs and administration of adenine arabinoside appeared to halt temporarily the progression of the disease in one eye and resulted in healing of the retinitis in the other eye. Subsequent progression of the more severely involved right eye resulted in an exudative retinal detachment and loss of vision prior to the patient's death from meningoencephalitis. Herpes simplex retinitis must be considered in the differential diagnosis of necrotizing retinitis in an immunosuppressed patient.