ASPIRIN PROPHYLAXIS OF VENOUS THROMBOEMBOLISM AFTER TOTAL HIP-REPLACEMENT
ASPIRIN PROPHYLAXIS OF VENOUS THROMBOEMBOLISM AFTER TOTAL HIP-REPLACEMENT
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DOI：
10.1056/nejm197712082972302
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发表时间：
1977-01-01
影响因子：
158.5
通讯作者：
DESANCTIS, RW
中科院分区：
文献类型：
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作者：
HARRIS, WH;SALZMAN, EW;DESANCTIS, RW
一项前瞻性、对照、双盲研究对 40 岁以上接受全髋关节置换术的患者进行了阿司匹林预防静脉血栓栓塞的评估。放射线静脉造影是诊断终点。接受阿司匹林治疗的 44 名患者中有 11 人出现血栓栓塞，而接受安慰剂的 51 名患者中有 23 人出现血栓栓塞（P < 0.03）。出乎意料的是，这种保护仅限于男性。服用阿司匹林的 23 名男性中有 4 名出现血栓，而服用安慰剂的 25 名男性中有 14 名出现血栓（P < 0.01）。女性的相应数字是 21 人中的 7 人，26 人中的 9 人。对接受阿司匹林治疗的相似患者组的审查显示，男性（15 人中的 3 人）的保护作用明显高于女性（27 人中的 15 人）（P < 0.03）。对于 40 岁以上的男性，每日两次服用 600 毫克阿司匹林可起到统计学上显着的预防作用。对女性缺乏保护作用仍无法解释。
Aspirin prophylaxis against venous thromboembolism was assessed in a prospective, controlled, double-blind study of patients over 40 yr of age who had undergone total hip replacement. Radiographic phlebography was the diagnostic end point. Thromboembolism developed in 11 of 44 patients receiving aspirin as compared to 23 of 51 receiving the placebo (P < 0.03). Unexpectedly this protection was limited to men. In 4 of 23 men on aspirin, thrombi developed as compared to 14 of 25 receiving placebo (P < 0.01). Corresponding figures for women were 7 of 21 vs. 9 of 26. Review of a similar group of patients receiving aspirin revealed significantly greater protection (P < 0.03) in men (3 of 15) than in women (15 of 27). Statistically significant prophylaxis is established in men over the age of 40 by 600 mg of aspirin given twice daily. The absence of a protective effect in women remains unexplained.