Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
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DOI：
10.1152/ajpregu.00399.2002
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发表时间：
2003-02-01
影响因子：
2.8
通讯作者：
Woods, SC
中科院分区：
文献类型：
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作者：
Clegg, DJ;Air, EL;Woods, SC
下丘脑外侧 (LH) 在控制进食和饮水方面发挥着关键作用。黑色素浓缩激素 (MCH) 是一种主要在 LH 中产生的促食欲肽能神经递质，而刺鼠相关蛋白 (AgRP) 是一种仅在支配 LH 的弓状区 (ARC) 中产生的促食欲肽能神经递质。我们评估了第三心室 (i3vt) 给予 MCH 和 AgRP 后的饮酒和进食情况。在昼夜周期的白天或黑暗部分服用 MCH（2.5、5 和 10 杯 i3vt）可显着增加 4 小时内的食物和水摄入量。当给老鼠喝 MCH（5 杯）但不给食物时，它们喝的水明显多于给予媒介物的情况。另一方面，AgRP（7 杯 i3vt）增加了水摄入量，但仅与黑暗和光照期间的食物摄入量成比例，并且在没有食物的情况下，i3vt AgRP 后水摄入量没有增加。因此，与 AgRP 相比，MCH 会导致水摄入量增加，而与食物摄入量无关。这些结果与将 LH 活动与水和食物摄入联系起来的历史数据一致。
The lateral hypothalamus (LH) has a critical role in the control of feeding and drinking. Melanin-concentrating hormone (MCH) is an orexigenic peptidergic neurotransmitter produced primarily in the LH, and agouti-related protein (AgRP) is an orexigenic peptidergic neurotransmitter produced exclusively in the arcuate (ARC), an area that innervates the LH. We assessed drinking and eating after third ventricular (i3vt) administration of MCH and AgRP. MCH (2.5, 5, and 10 mug i3vt) significantly increased food as well as water intake over 4 h when administered during either the light or the dark portion of the day-night cycle. When MCH (5 mug) was administered to rats with access to water but no food, they drank significantly more water than when given the vehicle. AgRP (7 mug i3vt), on the other hand, increased water intake but only in proportion to food intake during the dark and the light, and water intake was not increased after i3vt AgRP in the absence of food. Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake.