The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat
The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat
复制标题
补充生物合成胰岛素样生长因子-1 对新生大鼠体细胞生长、成熟和红细胞生成的影响
作者：
A. Philipps;B. Persson;K. Hall;M. Lake;A. Skottner;T. Sanengen;V. Sara
摘要：生长调节素是合成代谢激素，可刺激围产期生长。为了验证这一假设，新生大鼠在出生后的前 2 周每天注射两次生物合成的生长调节素、胰岛素样生长因子 1 (IGF-1)。在五窝大鼠中测试了两种不同效力的生物合成 IGF-1 制剂以及人类生长激素制剂。与注射生理盐水的大鼠相比，注射IGF-1的大鼠体重和尾长有所增加，并且肝脏、大脑、心脏和睾丸的重量也有特定增加。此外，注射IGF-1后，骨髓红细胞前体细胞明显增加。 IGF-1 治疗的新生大鼠也表现出早熟睁眼，这是上皮细胞分化的标志。另外五窝老鼠接受了类似的注射，但通过人为增加窝产数而遭受产后营养缺乏。尽管 IGF-1 会刺激骨髓红细胞生成和早熟睁眼，但没有记录到 IGF-1 对体细胞或器官生长的影响。这代表了 IGF-1 在快速生长的新生大鼠体内的合成代谢作用的首次体内证明，但表明营养充足对于充分表达生长调节素作用也可能是必要的。
ABSTRACT: Somatomedins are anabolic hormones that may stimulate growth during the perinatal period. To test this hypothesis, neonatal rats were injected with a biosynthetic somatomedin, insulin-like growth factor 1 (IGF-1) twice daily for the first 2 wk of life. Two biosynthetic IGF-1 preparations of different potency were tested as well as a preparation of human growth hormone in five litters of rats. When compared to saline-injected rats, IGF-1 injected rats had increased body weight and tail length as well as specific increases in weights of liver, brain, heart, and testes. In addition, significant increases in bone marrow erythropoietic cell precursors were apparent after IGF-1 injection. IGF-1-treated neonatal rats also exhibited precocious eye opening as a sign of epithelial cell differentiation. Five additional litters of rats received similar injections but were exposed to postnatal nutritional deprivation via artificially increasing litter size. Although IGF-1 caused stimulation of bone marrow erythropoiesis and precocious eye opening, no effects of IGF-1 on somatic or organ growth could be documented. This represents the first demonstration in vivo of the anabolic effects of IGF-1 in rapidly growing neonatal rats but suggests that nutritional sufficiency may also be necessary for the full expression of somatomedin effects.
牛关节软骨细胞高密度原代单层培养物上特定胰岛素样生长因子-I/生长调节素-C 受体的表征：生长调节素、胰岛素和生长激素对受体浓度的调节。
DOI：
10.1677/joe.0.1070275
发表时间：
1985
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Watanabe,N;Rosenfeld,RG;Hintz,RL;Dollar,LA;Smith,RL
通讯作者：
Smith,RL
小鼠发育过程中生长调节素的个体发育。
影响因子：
2.7
作者：
D'Ercole,AJ;Underwood,LE
通讯作者：
Underwood,LE