Mitochondrial DNA control region sequences from Nairobi (Kenya):: inferring phylogenetic parameters for the establishment of a forensic database
Mitochondrial DNA control region sequences from Nairobi (Kenya):: inferring phylogenetic parameters for the establishment of a forensic database
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DOI：
10.1007/s00414-004-0466-z
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发表时间：
2004-10-01
影响因子：
2.1
通讯作者：
Parsons, TJ
中科院分区：
文献类型：
--
作者：
Brandstätter, A;Peterson, CT;Parsons, TJ
大型法医线粒体DNA数据库遵循严格的生成和维护指南，不适用于美国和西欧以外的许多人群。我们已经建立了一个高质量的城市内罗毕的mtDNA控制区序列数据库作为法医调查的参考数据库，并作为一种工具，以检查肯尼亚序列的遗传变异的背景下，已知的非洲变异。内罗毕序列表现出高变异和低随机匹配概率，表明法医学检验的实用性。单倍型组识别和频率进行了比较，从其他已发表的研究报告的非洲，或非洲起源的人口从莫桑比克，塞拉利昂，和美国，并建议在不同的人群的mtDNA组成的显着差异。在我们的研究中的序列数据的质量进行了调查，并支持使用系统发育的措施。我们的数据显示了非洲人口的多样性和独特性，并强调了建立更多的非洲土著人口法医mtDNA数据库的重要性。
Large forensic mtDNA databases which adhere to strict guidelines for generation and maintenance, are not available for many populations outside of the United States and western Europe. We have established a high quality mtDNA control region sequence database for urban Nairobi as both a reference database for forensic investigations, and as a tool to examine the genetic variation of Kenyan sequences in the context of known African variation. The Nairobi sequences exhibited high variation and a low random match probability, indicating utility for forensic testing. Haplogroup identification and frequencies were compared with those reported from other published studies on African, or African-origin populations from Mozambique, Sierra Leone, and the United States, and suggest significant differences in the mtDNA compositions of the various populations. The quality of the sequence data in our study was investigated and supported using phylogenetic measures. Our data demonstrate the diversity and distinctiveness of African populations, and underline the importance of establishing additional forensic mtDNA databases of indigenous African populations.