Cutting edge:: Oral type I IFN-τ promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate
Cutting edge:: Oral type I IFN-τ promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate
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DOI：
10.4049/jimmunol.169.5.2231
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发表时间：
2002-09-01
影响因子：
4.4
通讯作者：
Zamvil, SS
中科院分区：
文献类型：
--
作者：
Soos, JM;Stüve, O;Zamvil, SS
IFN-tau是一种具有免疫调节特性的新型I型IFN，其缺乏通常与其他I型IFN相关的毒性。我们研究了单独口服IFN-tau和口服醋酸格拉替雷联合治疗实验性过敏性脑脊髓炎（EAE）的效果。通过比较口服IFN-α、IFN-β和IFN-tau对髓鞘碱性蛋白特异性TCR转基因小鼠的影响，我们证明了这些I型IFN以相似的效率促进Th2细胞因子IL-10的分泌。而IFN-α和IFN-β诱导IFN-γ分泌，一种Th1细胞因子，IFN-tau没有。单独口服IFN-tau抑制EAE。当向野生型小鼠联合口服次优剂量时，IFN-tau和醋酸格拉替雷在抑制EAE方面具有协同有益作用。这种组合与TGF-β分泌和增强的IL-10产生相关。因此，IFN-tau是用作多发性硬化症的单一药剂或组合疗法的潜在候选者。
IFN-tau, a novel type I IFN that possesses immunomodulatory properties, lacks toxicity normally associated with other type I IFNs. We examined the effects of oral IFN-tau alone and in combination with oral glatiramer acetate in experimental allergic encephalomyelitis (EAE). By comparison of oral administration of IFN-alpha, -beta, and -tau to myelin basic protein-specific TCR-transgenic mice, we demonstrate these type I IFNs promote secretion of the Th2 cytokine IL-10 with similar efficiency. Whereas IFN-alpha and -beta induced IFN-gamma secretion, a Th1 cytokine, IFN-tau did not. Oral IFN-tau alone suppressed EAE. When suboptimal doses were administered orally in combination to wild-type mice, IFN-tau and glatiramer acetate had a synergistic beneficial effect in suppression of EAE. This combination was associated with TGF-beta secretion and enhanced IL-10 production. Thus, IFN-tau is a potential candidate for use as a single agent or in combination therapy for multiple sclerosis.