A small-angle X-ray scattering study of local variations within powder compacts
A small-angle X-ray scattering study of local variations within powder compacts
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DOI：
10.1016/j.powtec.2009.01.010
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发表时间：
2009-06-25
影响因子：
5.2
通讯作者：
Cameron, Ruth E.
中科院分区：
文献类型：
--
作者：
Laity, Peter R.;Cameron, Ruth E.
本工作使用二维小角X射线散射（2D-SAXS）研究预胶化淀粉（PGS）和微晶纤维素（MCC）的压实行为，这是常用的药用辅料。通过分析散射强度的方位角变化，发现压实压力、相对密度和每种材料的2D-SAXS图案形状变化之间存在可重复的关系。这些结果表明，PGS和MCC之间的压实机制的差异。的关系也提供了一种手段，调查使用不同的材料和压实条件制备的试样内的压实行为的局部变化。相对密度的结果从2D-SAXS是一致的预期的基础上，在压实过程中的摩擦的影响，并出现类似的数据从其他方法。此外，然而，2D-SAXS测量结果显示，局部变化的有效方向，其中压实发生，与显着的径向分量附近的模具壁观察。这似乎与一些压实压力转移到模具壁上的摩擦力是一致的。这些观察结果代表了一个重要的进步，因为其他实验方法不容易揭示力在粉末压块内的传递方向。(c)2009爱思唯尔有限公司版权所有。
This work used two-dimensional small-angle X-ray scattering (2D-SAXS) to investigate the compaction behaviour of pre-gelatinised starch (PGS) and microcrystalline cellulose (MCC), which are commonly used as pharmaceutical excipients. By analysing azimuthal variations in scattering intensity, reproducible relationships were found between the compaction pressure, relative density and changes in the shapes of 2D-SAXS patterns for each material. These results indicated differences in the compaction mechanisms between PGS and MCC.The relationships also provided a means for investigating local variations in compaction behaviour within specimens prepared using different materials and compaction conditions. Relative density results from 2D-SAXS were consistent with expectations based on the effects of friction during compaction and appeared similar to data from other methods. In addition, however, 2D-SAXS measurements revealed local variations in the effective direction in which compaction occurred, with significant radial components observed near the die walls. This appeared to be consistent with the transfer of some compaction pressure to friction on the die wall. These observations represent an important advance, since other experimental methods do not easily reveal the direction of force transmission within the powder compact. (c) 2009 Elsevier B.V. All rights reserved.