The in vitro and in vivo effects of mefloquine on Trypanosoma brucei brucei.
The in vitro and in vivo effects of mefloquine on Trypanosoma brucei brucei.
复制标题
甲氟喹对布氏锥虫的体外和体内作用。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
Onabanjo Ao
中科院分区：
文献类型：
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作者：
Otigbuo In;Onabanjo Ao
在含有不同浓度甲氟喹的最低必需培养基中，布氏锥虫的血流形式在小鼠肾（MK）细胞上生长。观察到该药物在体外抑制寄生虫的增殖。雄性白化病小鼠在T. B.布氏杆菌感染以0.03 mg/kg体重连续4天给予甲氟喹清除了感染。在从血液中清除寄生虫后90天及以上，在这些小鼠的血液中未检测到锥虫。体外和体内治疗的剂量均远低于人类处方剂量。
Blood stream forms of Trypanosoma brucei brucei were grown over mouse kidney (MK) cells in minimum essential medium with various concentrations of mefloquine. The drug was observed to inhibit multiplication of the parasites in vitro. Groups of male albino mice were treated with mefloquine at 24, 48 and hours after T. b. brucei infection. Mefloquine at 0.03 mg/kg body weight administered for 4 consecutive days cleared the infection. No trypanosomes were detected in the blood of these mice for 90 days and over after the clearance of parasite from the blood. The doses for both the in vitro and in vivo therapy, were well below those prescribed for humans.