Computational Modeling of Oxygen Transfer in Artificial Lungs
Computational Modeling of Oxygen Transfer in Artificial Lungs
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人工肺氧转移的计算模型
DOI：
10.1111/aor.13146
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发表时间：
2018
影响因子：
2.4
通讯作者：
Arens J
中科院分区：
文献类型：
--
作者：
Kaesler A;Rosen M;Schmitz-Rode T;Steinseifer U;Arens J
在生理条件下，血液中高达97%的氧气从肺部运输到组织，与血红蛋白结合。为了利用计算流体动力学（CFD）在膜纤维水平上预测人工肺中的氧传递，先前的研究者已经将血红蛋白-氧相互作用纳入有效扩散系数中以修改对流扩散方程。根据我们自己的模拟和实验，这些方法往往会大大高估氧转移。本研究介绍了一种新的方法来模拟血液中的氧传递纤维水平上的CFD。血浆和红细胞作为两相实施，血红蛋白和氧气对氧合血红蛋白的反应以源项的形式包含在对流扩散方程中。该模型是用商业软件Ansys CFX 18.1。在多种血流条件下，将CFD模拟与三种交错纤维配置的微氧合器的体外实验进行了比较。为了校准模型，引入反应速率R 0，并将实验数据拟合到50 mL/h的血液流量。相对于体外结果，我们的模型近似了氧转移速率，对于20和90 mL/h的血流，差异分别为-23.7%和+6.3%。采用之前作者使用的有效扩散率模型进行比较，并估算出相对于体外数据的氧转移率，对于20、50和90 mL/h的血流，差异分别为+13.7%、+68.8%和+121.0%。一个成熟的数值传质相关性接近气体传递，参考平均体外数据，对于20、50和90 mL/h的血流量，差异分别为31.8%、13.1%和5.0%。即使结果是有希望的，模型的彻底验证将需要广泛的计算流体动力学和多个纤维排列，纤维直径，因此在未来的纤维束孔隙率的体外研究。这篇文章应该被理解为第一个可行性研究，以评估新的氧转移模型的潜力。
Under physiological conditions, up to 97% of the oxygen in blood that is transported from lungs to tissue is bound to hemoglobin. To predict oxygen transfer in artificial lungs on a membrane fiber level with computational fluid dynamics (CFD), previous investigators have incorporated the hemoglobin‐oxygen interaction into an effective diffusivity coefficient to modify the convection‐diffusion equation. Based on our own simulations and experiments, these approaches tend to significantly overestimate the oxygen transfer. The present study introduces a novel approach to model the oxygen transfer in blood on a fiber level with CFD. Plasma and red blood cells were implemented as two phases and the reaction of hemoglobin and oxygen to oxyhemoglobin was included in the convection‐diffusion equation in form of a source term. The model was implemented with the commercial software Ansys CFX 18.1. CFD simulations were compared with in vitro experiments on three micro oxygenators with a staggered fiber configuration under multiple blood flow conditions. To calibrate the model, a reaction rateR0was introduced and experimental data was fitted to a blood flow of 50 mL/h. Our model approximated the oxygen transfer rates with a difference, relative to in vitro results, of −23.7 and +6.3% for blood flows of 20 and 90 mL/h, respectively. The effective diffusivity model, used by previous authors, was implemented for comparison and approximated oxygen transfer rates with a difference, relative to in vitro data, of +13.7, +68.8, and +121.0% for blood flows of 20, 50, and 90 mL/h, respectively. A well‐established numerical mass transfer correlation approximated the gas transfer with a difference, referenced on the average in vitro data, of 31.8, 13.1, and 5.0% for blood flows of 20, 50, and 90 mL/h, respectively. Even though results are promising, a thorough validation of the model will require extensive CFD and in vitro studies of multiple fiber arrangements, fiber diameters, and therefore fiber bundle porosities in the future. This article should be understood as a first feasibility study to evaluate the potential of the novel oxygen transfer model.
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紧凑型横流管式氧合器。
DOI：
--
发表时间：
1985
期刊：
Transactions - American Society for Artificial Internal Organs
影响因子：
--
作者：
L. Mockros;R. Leonard
通讯作者：
R. Leonard
血红蛋白扩散对红细胞吸收和释放氧气的影响。
DOI：
--
发表时间：
1968
期刊：
Respiration Physiology
影响因子：
--
作者：
Waldemar Moll
通讯作者：
Waldemar Moll
DOI：
--
发表时间：
1993
期刊：
影响因子：
--
作者：
Karen L. Wang;E. Cussler
通讯作者：
E. Cussler
氧气转移到圆管中流动的血液，包括玻尔效应和霍尔丹效应
DOI：
--
发表时间：
1967
期刊：
影响因子：
--
作者：
J. C. Fair;M. Weissman
通讯作者：
M. Weissman
人体血红蛋白氧合速度的研究。
DOI：
--
发表时间：
1966
期刊：
The Japanese Journal of Physiology
影响因子：
--
作者：
Masaji Mochizuki;Ko Nakamura;Yotaro Oyama
通讯作者：
Yotaro Oyama