Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.
Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.
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DOI：
10.1007/978-1-4939-0473-0_54
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Rahme LG
中科院分区：
文献类型：
--
作者：
Hazan R;Maura D;Que YA;Rahme LG
Bacterial persistence, which is observed in a broad range of microbial species, is the capacity of a bacterial cell subpopulation called “persisters” to tolerate exposure to normally lethal concentrations of bactericidal antibiotics. This ability, which is not due to antibiotic-resistant mutants, has been implicated in antibiotic treatment failures and may account for latent, chronic, and relapsing infections. Antibiotic tolerant/Persister (AT/P) cells have been notoriously difficult to study due to their low frequency and transient nature. This chapter describes the main methods used to isolate and study Pseudomonas aeruginosa AT/P cells and discusses new technologies that may ease research of P. aeruginosa persisters in the near future.
