Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites.
Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites.
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DOI：
10.1111/j.1600-065x.2008.00713.x
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发表时间：
2008-12
影响因子：
8.7
通讯作者：
Artis D
中科院分区：
文献类型：
--
作者：
Saenz SA;Taylor BC;Artis D
有令人信服的证据表明，粘膜表面的上皮细胞（EC），除了它们在创造物理屏障中的作用外，还是先天性和适应性免疫的组成部分。这些细胞许可气道和胃肠道中特异性免疫细胞群功能的能力提供了靶向屏障免疫失调的多种炎性疾病的新治疗策略的前景。在这篇综述中，我们讨论了EC衍生的胸腺基质淋巴细胞生成素（TSLP），白细胞介素-25（IL-25）和IL-33在T辅助细胞2（Th 2）细胞因子依赖性免疫反应的发展和调节中的关键功能。我们首先强调最近的数据，提供了新的见解的因素，控制表达的这三个细胞因子及其受体。此外，我们还综述了它们在粘膜感染和炎症模型中的促炎和免疫调节功能。最后，我们讨论了新的发现，表明尽管它们的不同结构特征和受体的差异表达，TSLP，IL-25和IL-33相互交叉调节，并共享影响粘膜部位Th 2细胞因子依赖性反应的重叠特性。
There is compelling evidence that epithelial cells (ECs) at mucosal surfaces, beyond their role in creating a physical barrier, are integral components of innate and adaptive immunity. The capacity of these cells to license the functions of specific immune cell populations in the airway and gastrointestinal tract offers the prospect of novel therapeutic strategies to target multiple inflammatory diseases in which barrier immunity is dysregulated. In this review, we discuss the critical functions of EC‐derived thymic stromal lymphopoietin (TSLP), interleukin‐25 (IL‐25), and IL‐33 in the development and regulation of T‐helper 2 (Th2) cytokine‐dependent immune responses. We first highlight recent data that have provided new insights into the factors that control expression of this triad of cytokines and their receptors. In addition, we review their proinflammatory and immunoregulatory functions in models of mucosal infection and inflammation. Lastly, we discuss new findings indicating that despite their diverse structural features and differential expression of their receptors, TSLP, IL‐25, and IL‐33 cross‐regulate one another and share overlapping properties that influence Th2 cytokine‐dependent responses at mucosal sites.