Elucidation of the Biosynthesis and Degradation of Allantofuranone by Isotopic Labelling and Fermentation of Modified Precursors
Elucidation of the Biosynthesis and Degradation of Allantofuranone by Isotopic Labelling and Fermentation of Modified Precursors
复制标题
通过同位素标记和修饰前体发酵阐明尿囊呋喃酮的生物合成和降解
作者：
A. Schüffler;J. Liermann;T. Opatz;T. Anke
用子囊菌Allantophomopsis lycopodina进行的饲养实验表明，有效的抑真菌性尿囊呋喃酮是由苯丙氨酸生物合成的。对合成前体的进一步实验证明，天然存在的多孔酸是生物合成中的关键中间体。除了尿囊呋喃酮的形成，其非生物和代谢降解进行了研究。
Feeding experiments with the ascomycete Allantophomopsis lycopodina indicated that the potent fungistatic allantofuranone is biosynthesized from phenylalanine. Further experiments with synthetic precursors gave evidence that the naturally occurring polyporic acid serves as a key intermediate in the biosynthesis. In addition to the formation of allantofuranone, its abiotic and metabolic degradation were investigated.