IL-18 in patients with multiple sclerosis
IL-18 in patients with multiple sclerosis
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DOI：
10.1034/j.1600-0404.2001.00356.x
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发表时间：
2001-09-01
影响因子：
3.5
通讯作者：
Niezgoda, A
中科院分区：
文献类型：
--
作者：
Losy, J;Niezgoda, A
IL-18是一种细胞因子，通过诱导T细胞和NK细胞产生干扰素-γ，在Th-1应答中发挥重要作用。本研究测定了21例复发缓解型MS患者、9例MRI有Gd强化活动性病变患者和12例无强化病变患者血清和脑脊液中IL-18水平，并与诊断为神经衰弱和紧张性头痛的I级患者作为对照组进行比较。用双抗体夹心法测定脑脊液和血清中IL-18的浓度。我们发现MS患者IL-18、CSF和血清水平与对照组相比均有非常显著的升高。在MRI有活动性病变的患者中，脑脊液和血清中的IL-18水平明显高于无强化病变的患者。提示IL-18参与了MS的免疫发病机制，尤其是在疾病的活动期。
IL-18 is a cytokine which plays an important role in Th-1 response through its ability to induce IFN-gamma production in T cells and NK cells. The purpose of the study was to measure IL-18 levels in serum and CSF of 21 patients with the relapsing-remitting form of MS, 9 with active gadolinium enhancing lesions in MRI and 12 without enhancing lesions, and to compare results with control group consisting of I I patients with diagnosis of neurasthenia and tension headache. IL-18 concentration in the CSF and sera was measured by ELISA. We found a highly significant increase of both IL-18 CSF and serum levels in MS patients in comparison with the control group. In patients with active MRI lesions the levels of IL-18 in CSF and serum were significantly higher in comparison with the levels found in patients without enhancing lesions. The results suggest involvement of IL-18 in immunopathogenesis of MS especially in the active stages of the disease.