Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.
Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.
复制标题
多个锁滑键的断裂：两种状态双路径锁滑键。
DOI：
10.1140/epje/i2013-13133-9
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Gupta,VK
中科院分区：
文献类型：
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作者：
Gupta,VK
摘要我们用蒙特卡罗方法模拟了多形核白细胞（PMN）在牛顿流体中的分离过程，并通过多个捕获滑移键粘附在基底上。我们发现，在一定的加载速率的相互作用的多个捕捉滑移债券导致双峰分布的债券破裂力。我们还发现，在这些键断裂力分布的低力峰切换到一个高的力峰的加载速率逐渐增加。键断裂力分布的这些趋势是两态系统的特征。因此，虽然单个的捕获滑移键遵循一态双通道能量景观，但它们的相互作用模仿了一个两态双通道能量景观。图形摘要
AbstractWe performed Monte Carlo simulation of the detachment of a polymorphonuclear (PMN) leukocyte immersed in a Newtonian fluid and adhered to a substrate by multiple catch-slip bonds. We found that at certain loading rates the interplay of multiple catch-slip bonds leads to a bimodal distribution of the bond rupture force. We also found that the low force peak in these bond rupture force distributions switches to a high force peak with a gradual increase in the loading rate. These trends in the bond rupture force distributions are characteristics of two-state systems. Consequently, though individual catch-slip bonds follow one-state two-pathway energy landscape, their interplay mimics a two-state two-pathway energy landscape.Graphical abstract