Network of vascular-associated dendritic cells in intima of healthy young individuals
Network of vascular-associated dendritic cells in intima of healthy young individuals
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DOI：
10.1161/01.atv.21.4.503
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发表时间：
2001-04-01
影响因子：
8.7
通讯作者：
Wick, G
中科院分区：
文献类型：
--
作者：
Millonig, G;Niederegger, H;Wick, G
在早期的研究中，我们的小组已经建立了一个新的动脉粥样硬化形成的“免疫学”假说，实验和临床研究表明，针对热休克蛋白60的炎症免疫反应启动了动脉粥样硬化的发展。在本研究中，我们描述了一个迄今未知的树突状细胞网络的发现，在动脉的最内层，内膜，但不是健康的人和兔子的静脉。这些树突状细胞的数量与皮肤中的朗格汉斯细胞相当，树突状细胞显示出相似的表型（CD 1a + S-100（+）lag（+）CD 31（-）CD 83（-）CD 86（-），血管性血友病因子或平滑肌细胞肌球蛋白无染色）。这些血管相关的树突状细胞在那些动脉区域中积聚得最密集，这些动脉区域受到湍流条件下的主要血液动力学应激，并且已知其易于发生动脉粥样硬化。这些结果为动脉壁内免疫系统的激活开辟了新的前景。
In earlier studies, our group has established a new "immunological" hypothesis for atherogenesis supported by experimental and clinical studies showing that inflammatory immunological reactions against heat shock protein 60 initiate the development of atherosclerosis. In the present study, we describe the discovery of a so-far-unknown network of dendritic cells in the innermost layer of arteries, the intima, but not veins of healthy humans and rabbits. The number of these dendritic cells is comparable to that of Langerhans cells in the skin, and dendritic cells show a similar phenotype (CD1a+ S-100(+) lag(+) CD31(-) CD83(-) CD86(-) and no staining for von Willebrand factor or smooth muscle cell myosin). These vascular-associated dendritic cells accumulate most densely in those arterial regions that are subjected to major hemodynamic stress by turbulent flow conditions and are known to be predisposed for the later development of atherosclerosis. These results open new perspectives for the activation of the immune system within the arterial wall.