Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads.
Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads.
复制标题
接触全氟烷基和多氟烷基物质对母婴二人粪便微生物群组成的影响。
DOI：
10.1016/j.envint.2023.107965
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发表时间：
2023
影响因子：
11.8
通讯作者：
Orešič,Matej
中科院分区：
文献类型：
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作者：
Lamichhane,Santosh;Härkönen,Taina;Vatanen,Tommi;Hyötyläinen,Tuulia;Knip,Mikael;Orešič,Matej
越来越多的证据表明，化学品暴露会改变肠道微生物群的组成。然而，人们对全氟烷基和多氟烷基物质（PFAS）对肠道微生物群落的影响知之甚少。在这里，在一项母婴研究中，我们着手确定与出生前（母亲）和出生后（母亲，婴儿）化学暴露相关的肠道细菌种类。配对的血清和粪便样本收集自纵向设置的母婴二对（n = 30）。在母体血清中定量PFAS以检查它们与母亲和婴儿中的微生物组成（通过鸟枪法宏基因组测序确定）的关联。母体对PFAS的高暴露与母体粪便中史氏甲烷短杆菌丰度增加一致相关。在PFAS化合物中，PFOS和PFHpS与M的结合力最强。史密斯。然而，母体总PFAS暴露仅与婴儿微生物组弱相关。我们的研究结果表明，PFAS暴露会影响成人肠道微生物组的组成。
There is growing evidence suggesting that chemical exposure alters gut microbiota composition. However, not much is known about the impact of per- and polyfluoroalkyl substances (PFAS) on the gut microbial community. Here, in a mother-infant study, we set out to identify the gut bacterial species that associate with chemical exposure before (maternal) and after (maternal, infant) birth. Paired serum and stool samples were collected from mother-infant dyads (n = 30) in a longitudinal setting. PFAS were quantified in maternal serum to examine their associations with the microbial compositions (determined by shotgun metagenomic sequencing) in mothers and infants. High maternal exposure to PFAS was consistently associated with increased abundance ofMethanobrevibacter smithiiin maternal stool. Among individual PFAS compounds, PFOS and PFHpS showed the strongest association withM. smithii. However, maternal total PFAS exposure associated only weakly with the infant microbiome. Our findings suggest that PFAS exposure affects the composition of the adult gut microbiome.