CORRELATION IN THE DISCHARGES OF NEIGHBORING RAT RETINAL GANGLION-CELLS DURING PRENATAL LIFE
CORRELATION IN THE DISCHARGES OF NEIGHBORING RAT RETINAL GANGLION-CELLS DURING PRENATAL LIFE
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DOI：
10.1073/pnas.87.7.2861
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发表时间：
1990-04-01
影响因子：
11.1
通讯作者：
GALLIRESTA, L
中科院分区：
文献类型：
--
作者：
MAFFEI, L;GALLIRESTA, L
在胚胎第18天和第21天的麻醉的产前大鼠中，同时记录相邻视网膜神经节细胞的自发放电。我们在这里报告说，在大多数情况下，发射相邻的视网膜神经节细胞是密切相关的产前生活。在发育过程中，相邻细胞放电的相关性一直被认为是一种巩固与目标细胞的突触连接的方法，它们会聚在目标细胞上，这是Hebb首先提出的模型。视网膜中相邻神经元活动的相关性可能是发育过程的基础，例如大脑中视网膜图的细化和双眼输入的分离。
The spontaneous discharges of neighboring retinal ganglion cells were recorded simultaneously in anesthetized prenatal rats between embryonic days 18 and 21. We report here that in the majority of cases the firings of neighboring retinal ganglion cells are strongly correlated during prenatal life. Correlation in the discharges of neighboring cells during development has long been suggested as a way to consolidate synaptic connections with a target cell onto which they converge, a model first proposed by Hebb. Correlation in the activities of neighboring neurons in the retina could be the basis of developmental processes such as refinement of retinoptic maps in the brain and segregation of the inputs from the two eyes.