ON THE CONTROL OF GERM-CELL DEVELOPMENT IN CAENORHABDITIS-ELEGANS
ON THE CONTROL OF GERM-CELL DEVELOPMENT IN CAENORHABDITIS-ELEGANS
复制标题
DOI：
10.1016/0012-1606(81)90284-0
复制
发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
WHITE, JG
中科院分区：
文献类型：
--
作者：
KIMBLE, JE;WHITE, JG
秀丽隐杆线虫的种系祖细胞孵化后开始有丝分裂；随后，一些生殖系细胞进入减数分裂并分化成配子。在成人，有丝分裂生殖细胞，或干细胞，发现在远端和减数分裂细胞占据其余的细长性腺。激光显微手术切除2个性腺细胞（远端尖端细胞）对生殖细胞发育有显著影响。无论男女，这一操作都会导致生殖细胞有丝分裂的停止和减数分裂的开始。在完整的动物中，远端尖端细胞的功能似乎是抑制附近生殖细胞的减数分裂（或刺激有丝分裂）。在发育过程中，它允许生长，在成人中，它维持生殖系干细胞的数量。性腺末梢细胞在发育早期位置的改变与种系组织轴向极性的改变有关。在性腺远端定位远端尖细胞的抑制活性可以建立完整动物生殖系组织的轴向极性。
After hatching, the germ line progenitor cells in C. elegans begin to divide mitotically; later, some of the germ line cells enter meiosis and differentiate into gametes. In the adult, mitotic germ cells, or stem cells, are found at the distal end and meiotic cells occupy the rest of the elongate gonad. Removal of 2 somatic gonadal cells, the distal tipcells, by laser microsurgery has a dramatic effect on germ cell development. In either sex this operation leads to the arrest of mitosis and the initiation of meiosis in germ cells. The function of the distal tip cell in the intact animal appears to be the inhibition of meiosis (or stimulation of mitosis) in nearby germ cells. During development this permits growth and, in the adult, it maintains the germ line stem cell population. A change in the position of the distal tip cell in the gonad at an early point in development is correlated with a change in the axial polarity of the germ line tissue. The localization of the distal tip cell''s inhibitory activity at the distal end of the gonad may establish the axial polarity of the germ line tissue in the intact animal.