Neutral effect of recombination on base composition in Drosophila
Neutral effect of recombination on base composition in Drosophila
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DOI：
10.1017/s0016672302006079
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发表时间：
2003-04-01
影响因子：
1.5
通讯作者：
Duret, L
中科院分区：
文献类型：
--
作者：
Marais, G;Mouchiroud, D;Duret, L
重组被认为对基因组进化有不同的进化效应。在本研究中，我们研究了果蝇基因组中碱基组成与重组率之间的关系。由于目前对果蝇重组率估计的准确性存在争议，我们使用了最近工作中的八种不同的重组率测量方法。我们证实了果蝇大内含子和侧翼区的G+C含量与重组率呈正相关，表明重组对果蝇的碱基组成具有中性影响。我们还证实，重组的这种中性效应是果蝇同义密码子使用偏向与重组率之间相关性的主要决定因素。
Recombination is thought to have various evolutionary effects on genome evolution. In this study, we investigated the relationship between the base composition and recombination rate in the Drosophila melanogaster genome. Because of a current debate about the accuracy of the estimates of recombination rate in Drosophila, we used eight different measures of recombination rate from recent work. We confirmed that the G + C content of large introns and flanking regions is positively correlated with recombination rate, suggesting that recombination has a neutral effect on base composition in Drosophila. We also confirmed that this neutral effect of recombination is the main determinant of the correlation between synonymous codon usage bias and recombination rate in Drosophila.