The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults
The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults
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DOI：
10.1176/appi.ajp.2007.06122007
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发表时间：
2007-11-01
影响因子：
17.7
通讯作者：
Gelernter, Joel
中科院分区：
文献类型：
--
作者：
Kilpatrick, Dean G.;Koenen, Karestan C.;Gelernter, Joel
目的：灾难与创伤后应激障碍（PTSD）和重度抑郁症的风险增加有关，但据作者所知，没有研究确定基因型是否与灾难暴露和社会支持相互作用，以减轻这些表型的风险。作者检验了一个假设，即血清素转运体基因的多态性（位点，SLC 6A 4;变异体，5-羟色胺5-HTTLPR）在高飓风暴露和低社会支持的情况下，可调节飓风后PTSD和重性抑郁症的风险。作者在2004年飓风后6-9个月采访了一个成年人的家庭概率样本，内容涉及飓风暴露、社会支持，创伤后应激障碍和重度抑郁症从一部分参与者中收集DNA。参与者是来自佛罗里达38个县的589名18岁及以上的成年人，他们提供了有效的DNA样本。结果的措施是DSM-IV诊断的postthurvastPTSD和抑郁症来自结构化interviews.Results：5-HTTLPR多态性的低表达变体的postthurvastPTSD和抑郁症的风险增加，但只有在高飓风暴露和低社会支持的条件下调整后的性别，血统（由贝叶斯聚类的基因型），和年龄。对重度抑郁症也有类似的影响。高风险的个人（高飓风曝光，低表达5-HTTLPR变体，低社会支持）是4.5倍的风险发展PTSD和抑郁症的低风险individual.Conclusions：低表达的5-HTTLPR多态性的变体修改灾后PTSD和抑郁症的风险高飓风曝光和低社会支持的条件下，确认和扩展以前的研究。
Objective: Disasters are associated with increased risk of posttraurnatic stress disorder (PTSD) and major depression, but no study, to the authors' knowledge, has determined whether genotype interacts with disaster exposure and social support to moderate risk of these phenotypes. The authors tested the hypothesis that a polymorphism in the serotonin transporter gene (locus, SLC6A4; variant, serotonin 5-HTTLPR) moderates risk of posthurricane PTSD and major depression given high hurricane exposure and low social support.Method: The authors interviewed a household probability sample of adults 6-9 months after the 2004 hurricanes about hurricane exposure, social support, and posthurricane PTSD and major depression. DNA was collected from a subset of participants. Participants were 589 adults ages 18 and older from 38 Florida counties who provided valid DNA samples. Outcome measures were DSM-IV diagnoses of posthurricane PTSD and major depression derived from structured interviews.Results: The low-expression variant of the 5-HTTLPR polymorphism increased risk of posthurricane PTSD and major depression but only under the conditions of high hurricane exposure and low social support after adjustment for sex, ancestry (as determined by Bayesian clustering of genotypes), and age. Similar effects were found for major depression. High-risk individuals (high hurricane exposure, the low-expression 5-HTTLPR variant, low social support) were at 4.5 times the risk of developing PTSD and major depression of low-risk individuals.Conclusions: The low-expression variant of the 5-HTTLPR polymorphism modifies risk of postdisaster PTSD and major depression under conditions of high hurricane exposure and low social support, confirming and extending previous research.