Thymic pseudotumorous enlargement due to follicular hyperplasia in a human immunodeficiency virus sero-positive patient. Immunohistochemical and molecular biological study of viral infected cells.
Thymic pseudotumorous enlargement due to follicular hyperplasia in a human immunodeficiency virus sero-positive patient. Immunohistochemical and molecular biological study of viral infected cells.
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人类免疫缺陷病毒血清阳性患者因滤泡增生导致胸腺假瘤肿大。
DOI：
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发表时间：
1992
影响因子：
3.5
通讯作者：
J. Diebold
中科院分区：
文献类型：
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作者：
S. Prévôt;J. Audouin;J. André;R. Griffais;A. Le Tourneau;J. Fournier;J. Diebold
在一名患有早期获得性免疫缺陷综合征的28岁男子中发现了胸腺肿大，提示肿瘤。进行了活检。胸腺内陷脂肪，持续存在许多Hassall小体，被判定为大淋巴滤泡增生。这种滤泡增生类似于以前描述的淋巴结、脾脏和其他淋巴组织在人类免疫缺陷病毒感染早期阶段，在获得性免疫缺陷综合征的发展。在增生的生发中心（淋巴细胞和滤泡树突状感染细胞）以及滤泡间区的许多淋巴细胞和/或上皮细胞中检测到人类免疫缺陷病毒RNA和p24人类免疫缺陷病毒蛋白。该组织是阴性的EB病毒DNA序列，通过聚合酶链反应测定。这些观察结果确定了人类免疫缺陷病毒感染成人中胸腺感染的第一个状态，在所有已分析胸腺的获得性免疫缺陷综合征致死病例中观察到的严重退化伴淋巴耗竭之前。
An enlargement of the thymus suggesting a tumor was discovered in a 28-year-old man who had early-stage acquired immune deficiency syndrome. A biopsy was performed. The adipose involuted thymus, with persistence of many Hassall's corpuscles, was judged to be a large lymphoid follicular hyperplasia. This follicular hyperplasia was similar to that previously described for lymph nodes, spleen, and other lymphoid tissues at earlier stages of human immunodeficiency virus infection, before the development of acquired immune deficiency syndrome. Human immunodeficiency virus RNA and p24 human immunodeficiency virus protein were detected in the hyperplastic germinal centers (lymphocytes and follicular dendritic infected cells), and also in many cells that may have been either lymphocytes and/or epithelial cells in the interfollicular areas. The tissue was negative for Epstein-Barr virus DNA sequences, as determined by the polymerase chain reaction. These observations identify the first state of infection of the thymus in a human immune deficiency virus-infected adult, preceding the severe involution with lymphoid depletion observed in all fatal cases of acquired immunodeficiency syndrome in which the thymus has been analyzed.