Surface molecularly imprinted polymer core-shell particles
Surface molecularly imprinted polymer core-shell particles
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DOI：
10.1002/adfm.200305069
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发表时间：
2004-06-01
影响因子：
19
通讯作者：
Rimmer, S
中科院分区：
文献类型：
--
作者：
Carter, SR;Rimmer, S
采用水溶性模板分子，通过水乳液聚合制备了核壳分子印迹聚合物（CS-MIPs）。一个两亲性的结合单体，油烯基苯基磷酸氢酯和乙二醇二甲基丙烯酸酯用于形成高度交联的表面周围的二乙烯基苯交联聚苯乙烯核胶体。通过透射电子显微镜（TEM）的表面形态的变化时，在模板的存在下形成的聚合物壳的证据。的咖啡因印迹聚合物被证明优先结合咖啡因茶碱从等摩尔的混合物中的化合物在水溶液中，在pH 7.0，而浓度结合（Scatchard）曲线显示存在两个群体的结合位点在磷酸盐缓冲液中，在pH 8.0的咖啡因和茶碱。在pH5.5下对（S）-普萘洛尔和（S）-阿替洛尔也进行了类似的研究，这也揭示了用这些化合物印迹的核-壳颗粒存在两个结合位点群（population）。（S）-普萘洛尔通过两种CS-MIP从（S）-普萘洛尔和（S）-阿替洛尔的溶液中选择性地去除，而非印迹颗粒对任一组分都没有显示出选择性。
Core shell molecularly imprinted polymers (CS-MIPs) have been prepared by aqueous emulsion polymerization using water soluble template molecules. An amphiphilic binding monomer, oleyl phenyl hydrogen phosphate and ethylene glycol dimethyl acrylate were used in the formation of highly crosslinked surfaces around divinyl benzene crosslinked polystyrene core colloids. Evidence was obtained by transmission electron microscopy (TEM) for a change in surface morphology when the polymer shell was formed in the presence of a template. The caffeine imprinted polymers were shown to bind caffeine in preference to theophylline from an equimolar mixture of the compounds in aqueous solution at pH 7.0, whilst concentration-binding (Scatchard) curves revealed the presence of two populations of binding sites in aqueous phosphate buffer at pH 8.0 for caffeine and theophylline. Similar studies were also carried out for (S)-propranolol and (S)-atenolol at pH 5.5, which also revealed the presence of two populations of binding sited for core-shell particles imprinted with these compounds (S)-Propranolol was selectively removed from a solution of (S)-propranolol and (S)-atenolol by both of the CS-MIPs, whereas the non-imprinted particle showed no selectivity for either component.