Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke
Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke
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DOI：
10.1093/carcin/16.12.3031
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发表时间：
1995-12-01
期刊：
影响因子：
4.7
通讯作者：
Chuang, JC
中科院分区：
文献类型：
--
作者：
Mumford, JL;Li, XM;Chuang, JC
宣威县的肺癌死亡率是全国平均水平的5倍;妇女的死亡率是中国最高的，宣威居民在家中做饭或取暖时暴露于未通风的煤或木材烟雾中。本研究调查了XW居民使用煤烟型燃煤时室内空气中多环芳烃（PAHs）的暴露情况和剂量学特征，采用GC/MS法对4个XW居民家庭使用煤烟型燃煤时室内空气中的PAHs进行了分析，并对16名XW非吸烟女性和6名XW吸烟男性的尿样进行了分析。用CC/MS分析了8名昆明非吸烟对照和4名非吸烟美籍华人对照的多环芳烃和羟基多环芳烃，结果表明，XW居民存在职业水平的多环芳烃暴露。在XW家庭的室内空气中发现了强致癌物二苯并[α，l]芘（4.9 +/- 1.3 μ g/m3）。在大多数受试者中，尿中羟基-PAH的水平高于母体化合物的水平，表明大多数PAH被代谢。在尿中，9-羟基Bar（Bar）和BaP的平均水平为1.5 +/- 0.5 μ m/mol肌酐，XW男性为0.5 +/- 0.3 μ m/mol，XW妇女尿中PAH代谢物浓度分别为1.9 ± 0.9 μ m/mol和0.5 ± 0.3 μ m/mol。XW组与昆明对照组相比，仅9-羟基Bar含量差异有统计学意义（P < 0.05）。XW人群中3种甲基化多环芳烃的平均水平是母体多环芳烃的4.8倍，这与以前的研究结果一致，即烷基化多环芳烃是XW室内空气中的主要诱变剂，可能是XW肺癌的重要病因。
The lung cancer mortality rate in Xuan Wei (XW) county, China, is 5-fold the national average of China; the rate for women is the highest in China, Xuan Wei residents have been exposed to unvented coal or wood smoke during cooking or heating in homes. This study investigated indoor air exposure and dosimetry of polycyclic aromatic hydrocarbons (PAHs) in XW residents using smoky coal, Indoor air particles collected during cooking in four XW homes using smoky coal were analyzed for PAHs by GC/MS, Urine samples from 16 XW non-smoking women and six XW smoking men, eight Kunming non-smoking controls and four non-smoking Chinese American controls were analyzed for PAHs and hydroxy-PAHs by CC/Ms, The results showed that XW residents were exposed to PAHs at occupational levels. The potent carcinogen, dibenzo[alpha,l] pyrene (4.9 +/- 1.3 mu g/m(3)) was found in the indoor air of the XW homes. The levels of urinary hydroxy-PAH were higher than those of the parent compounds in most subjects, indicating that most PAHs were metabolized, In urine, the mean levels of 9-hydroxy Bar (Bar) and BaP are 1.5 +/- 0.5 mu mol/mol creatinine and 0.5 +/- 0.3 mu m/mol for XW men, 1.9 +/- 0.9 mu m/mol and 0.5 +/- 0.3 mu m/mol for XW women, In general, the levels of PAH metabolites in urine were higher in the XW residents than in Kunming and Chinese American controls; however only the concentrations of 9-hydroxy Bar in XW women showed statistically significant difference from the Kunming controls (P < 0.05 by ranking test). The mean levels of 3 methylated-PAHs analyzed were 4.8-fold higher than that of the parent PAHs in XW subjects, This is consistent with previous findings that alkylated PAHs are the major mutagens in the XW indoor air and may be etiologically important in XW lung cancer.