Biochemical evaluation of an artificial anal sphincter made from shape memory alloys
Biochemical evaluation of an artificial anal sphincter made from shape memory alloys
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DOI：
10.1007/s10047-007-0395-y
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发表时间：
2007-12
影响因子：
1.3
通讯作者：
Hongjian Liu;Yun Luo;M. Higa;Xiumin Zhang;Y. Saijo;Y. Shiraishi;K. Sekine;T. Yambe
中科院分区：
文献类型：
--
作者：
Hongjian Liu;Yun Luo;M. Higa;Xiumin Zhang;Y. Saijo;Y. Shiraishi;K. Sekine;T. Yambe
严重肛门失禁是一种社会失能障碍，是一个主要的未解决的临床问题，对生活质量有相当大的负面影响。本研究利用形状记忆合金（sma）研制了一种新型人工肛门括约肌，以改善该类患者的生活质量，并在动物实验中评估了该括约肌对血清化学的影响。人工肛门括约肌由两个Ti-Ni SMA致动器夹在肠道内驱动，植入3只母山羊体内。第1、4天颈静脉采血；第1周和第2周；术后1、2、3个月。检测生化指标包括总蛋白、白蛋白、总胆红素、天冬氨酸转氨酶、血尿素氮、肌酐、c反应蛋白。植入1周后，3只山羊的总胆红素和天冬氨酸氨基转移酶的时间进程均在基线水平内，保持正常，无肝功能并发症。血尿素氮、肌酐均在正常范围内，无肾功能并发症。在整个研究期间，总蛋白和白蛋白在正常范围内波动。在这些山羊中，还发现c反应蛋白的水平没有增加，并且连接人工括约肌的肠道没有狭窄。我们的研究结果表明，人工括约肌SMA对血清化学没有不良影响，并表现出有效的系统性能。
Severe anal incontinence is a socially incapacitating disorder and a major unresolved clinical problem that has a considerable negative impact on quality of life. In this study, we developed a new artificial anal sphincter using shape memory alloys (SMAs) in order to improve the quality of life of such patients and evaluated the influence of this sphincter on blood serum chemistry in animal experiments. The artificial anal sphincter was driven by two Ti-Ni SMA actuators sandwiching the intestine and was implanted in three female goats. Blood was collected from the jugular vein on days 1 and 4; at weeks 1 and 2; and at months 1, 2, and 3, postoperatively. Biochemical parameters including total protein, albumin, total bilirubin, aspartate amino-transferase, blood urea nitrogen, creatinine, and C-reactive protein were examined. The time courses of total bilirubin and aspartate amino transferase of the three goats were within the baseline levels after 1 week of implantation and remained normal, demonstrating no liver function complications. The blood urea nitrogen and creatinine levels remained within the normal range, indicating no renal function complications. The total protein and albumin fluctuated within the normal range throughout the duration of this study. In these goats, it was also found that the level of C-reactive protein did not increase and that there was no stricture of the intestine where the artificial sphincter was attached. Our findings indicate that the artificial sphincter SMA demonstrated no adverse influence on blood serum chemistry and exhibited an effective system performance.