DIFFERENCES BETWEEN LEAN AND OBESE ZUCKER RATS - EFFECT OF POORLY ABSORBED DIETARY LIPID ON ENERGY-INTAKE AND BODY-WEIGHT GAIN
DIFFERENCES BETWEEN LEAN AND OBESE ZUCKER RATS - EFFECT OF POORLY ABSORBED DIETARY LIPID ON ENERGY-INTAKE AND BODY-WEIGHT GAIN
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DOI：
10.1093/jn/108.5.826
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发表时间：
1978-01-01
影响因子：
4.2
通讯作者：
SULLIVAN, AC
中科院分区：
文献类型：
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作者：
COMAI, K;TRISCARI, J;SULLIVAN, AC
本实验观察了在Zucker瘦肉型和肥胖型Zucker大鼠日粮中添加吸收不良的脂肪(氢化大豆油)替代玉米油(CO)对大鼠摄食量、增重、血脂和胰脂酶活性的影响。在24天的研究中，大鼠饲喂20%的脂肪饲料。精瘦的雌性和雄性Zucker大鼠通过增加食物摄入量来补偿饮食中氢化大豆油(HO)的吸收不足。到第6天，精瘦的雄性Zucker大鼠已经完全代偿。喂食20%HO饲料的雌性Zucker大鼠也表现出代偿性吞噬亢进，但完全适应能力不如雄性大鼠。在研究的前18天，喂食HO饮食的雄性和雌性肥胖的Zucker大鼠并没有通过过度吞噬来弥补吸收不足的膳食脂肪，因此吸收的能量一直显著减少。从第18-24天开始，喂食HO饮食的肥胖大鼠似乎出现了代偿，尽管这种明显的代偿可能反映了在此期间喂食CO的大鼠食物摄入量的减少。摄入HO饮食导致瘦体和肥胖的Zucker大鼠粪便脂肪排泄增加，体重增加显著减少。与瘦子相比，肥胖大鼠的血脂和血糖水平显著升高。与喂食CO饮食的大鼠相比，喂食HO饮食的肥胖和瘦Zucker大鼠的血清甘油三酯、胆固醇、磷脂和葡萄糖水平降低。肥胖大鼠的胰腺脂肪酶[EC 3.1.1.3]活性高于瘦肉大鼠，而喂食HO饮食的大鼠的活性低于CO饮食的大鼠。
The effects of substitution of a poorly absorbable dietary lipid (hydrogenated soybean oil) for corn oil (CO) in the diets of lean and obese Zucker rats on food intake, weight gain, serum lipids and pancreatic lipase activity were observed. During the 24 day study the rats were fed 20% fat diets. The lean female and male Zucker rats compensated for the poorly absorbed dietary hydrogenated soybean oil (HO) by increasing food consumption. By day 6 the lean male Zucker rats had compensated fully. The lean female Zucker rats fed the 20% HO diet also demonstrated compensatory hyperphagia, but adjusted less completely than the males. Male and female obese Zucker rats fed the HO diet did not compensate for the poorly absorbed dietary lipid by hyperphagia during the first 18 days of the study, and thus consistently absorbed significantly less energy. Obese rats fed HO diets appeared to compensate from day 18-24, although this apparent compensation may reflect the decreased food intake of the CO fed rats during this time interval. The consumption of HO diet resulted in increased fecal fat excretion and significant reductions in body weight gain for lean and obese Zucker rats. Serum lipid and glucose levels were significantly increased in obese rats compared to their lean littermates. Obese and lean Zucker rats fed the HO diet exhibited decreases in serum triglycerides, cholesterol, phospholipids and glucose compared to rats fed the CO diet. Pancreatic lipase [EC 3.1.1.3] activities were higher in obese rats compared to lean, and lower in rats fed the HO diet compared to the CO diet.