Origin of oligodendrocytes in mammalian forebrains: a revised perspective.
Origin of oligodendrocytes in mammalian forebrains: a revised perspective.
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DOI：
10.1007/s12576-016-0479-7
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Hitoshi S
中科院分区：
文献类型：
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作者：
Naruse M;Ishizaki Y;Ikenaka K;Tanaka A;Hitoshi S
少突胶质细胞前体细胞（Oligodendrocyte precursor cells，OPCs）出现在胚胎晚期的脑中，成熟为少突胶质细胞（oligodendrocyte，OLs），并在出生后的脑中形成髓鞘。已经提出，来自腹侧前脑的早期出生的OPCs在出生后被消除，而晚期出生的OL在成年小鼠皮质中占主导地位。然而，皮质OL代，持续整个生命在成年哺乳动物的时间和区域生态位，仍有待确定。我们最近的研究为自我更新和多能神经干细胞（NSCs）提供了新的见解。我们的研究结果，加上以前的研究，表明，在背腹侧边界的神经干细胞是唯一专门生产髓鞘形成的OL在皮层在一个有限的时间窗口。这些发现可能有助于识别转录因子或基因表达模式，赋予神经前体细胞背腹侧边界NSC分化为OL的特征能力，并促进受损大脑再生医学的新策略的发展。
Oligodendrocyte precursor cells (OPCs) appear in the late embryonic brain, mature into oligodendrocytes (OLs), and form myelin in the postnatal brain. It has been proposed that early born OPCs derived from the ventral forebrain are eliminated postnatally and late-born OLs predominate in the adult mouse cortex. However, the temporal and regional niche for cortical OL generation, which persists throughout life in adult mammals, remains to be determined. Our recent study provides new insight into self-renewing and multipotent neural stem cells (NSCs). Our results, together with previous studies, suggest that NSCs at the dorsoventral boundary are uniquely specialized to produce myelin-forming OLs in the cortex during a restricted temporal window. These findings may help identify transcription factors or gene expression patterns which confer neural precursors with the characteristic ability of dorsoventral boundary NSCs to differentiate into OLs, and facilitate the development of new strategies for regenerative medicine of the damaged brain.