The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions.
The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions.
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小鼠 Hoxc 簇包含五个相邻的 AbdB 相关 Hox 基因，这些基因在后胚胎亚区域显示出独特的空间协调表达。
DOI：
10.1016/0925-4773(94)90043-4
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发表时间：
1994
影响因子：
2.6
通讯作者：
Awgulewitsch,A
中科院分区：
文献类型：
--
作者：
Peterson,RL;Papenbrock,T;Davda,MM;Awgulewitsch,A
A common feature of the murineAbdominal B (AbdB)-related Hox genes, located in the 5′ regions of the four Hox clusters, appears to be a function in patterning the developing limb. As a prerequisite for studying the role of theAbdB-relatedHoxcgenes during limb development, we have isolated and mapped the three predictedAbdB-relatedHoxc-11, -12, and-13loci, thus defining the 5′ end of theHoxccluster. Sequence comparisons based on the homeobox sequences of presumably all murineAbdB-related Hox genes strongly support the concept of a two step process in their evolution. As expected,Hoxc-11, -12and-13exhibit nested and extremely posteriorly restricted expression domains, whose anterior boundaries reflect their map positions, in accordance with the colinearity rule. A limited comparison of the primary expression domains of all fiveAbdB-relatedHoxcgenes in the developing hindlimb revealed nested and increasingly restricted domains of expression in the mesenchyme for onlyHoxc-9, -10and-11. However, separate localized expression was detected forHoxc-9, -10, -11, -12and possibly-13in distal epidermal regions of the developing hind- and forelimb, whereas no expression of any of the five genes was observed in mesenchymal tissues of the developing forelimb. These data suggest a specific role for theAbdB-relatedHoxcgenes in patterning the hindlimb and pelvic girdle, which is separate from a second role relevant for both hind- and forelimb development.
