Ipilimumab-induced hypophysitis involving the optic tracts and tuber cinereum evaluated using 3D fluid-attenuated inversion recovery.
Ipilimumab-induced hypophysitis involving the optic tracts and tuber cinereum evaluated using 3D fluid-attenuated inversion recovery.
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DOI：
10.1016/j.radcr.2017.11.007
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发表时间：
2018-03
影响因子：
--
通讯作者：
Sakuma H
中科院分区：
文献类型：
--
作者：
Tanaka F;Kogue R;Maeda M;Umino M;Nakai Y;Takeshita A;Sakuma H
易普利姆玛（Ipilimumab）是一种针对细胞毒性T淋巴细胞抗原4的人单克隆抗体，于2011年获得美国FDA（食品和药物管理局）批准用于治疗不可切除或转移性恶性黑色素瘤。垂体炎的发生是一种因使用易普利姆玛而引起的免疫相关不良事件，已被频繁报道。我们报告了一例 ipilimumab 引起的垂体炎，涉及视束和灰结节，使用 3D 流体衰减反转恢复进行识别。
Ipilimumab, a human monoclonal antibody against cytotoxic T-lymphocyte antigen 4, was approved by the U.S. FDA (Food and Drug Administration) in 2011 for the treatment of unresectable or metastatic malignant melanoma. Occurrence of hypophysitis, an immune-related adverse event due to ipilimumab use, has been frequently reported. We report a case of ipilimumab-induced hypophysitis involving the optic tracts and tuber cinereum, identified using 3D fluid-attenuated inversion recovery.