Hyaluronan cross-linking: a protective mechanism in inflammation?
Hyaluronan cross-linking: a protective mechanism in inflammation?
复制标题
DOI：
10.1016/j.it.2005.09.009
复制
发表时间：
2005-12-01
影响因子：
16.8
通讯作者：
de la Motte, CA
中科院分区：
文献类型：
--
作者：
Day, AJ;de la Motte, CA
在炎症部位，糖胺聚糖透明质酸的产生增加，通常与白细胞的聚集有关。越来越多的证据表明，这种多糖可以通过与特定结合蛋白的结合而形成多种分子结构，从而形成含有大量透明质酸链的纤维和索状结构。我们认为，透明质酸交联是一种保护机制的一部分，促进白细胞与透明质酸复合体的黏附，而不是使其能够与底层组织上的促炎受体接触。因此，通过适当的受体聚集或受体共同参与，白细胞保持在非激活状态。此外，透明质酸网络可以作为支架，防止炎症过程中细胞外基质成分的丢失，并隔离促炎介质。
Production of the glycosaminoglycan hyaluronan is increased at sites of inflammation, often correlating with the accumulation of leukocytes. Mounting evidence suggests that this polysaccharide can be organized into a wide variety of molecular architectures by its association with specific binding proteins, leading to the formation of fibrils and cable-like structures involving a large number of hyaluronan chains. We propose that hyaluronan cross-linking is part of a protective mechanism, promoting adhesion of leukocytes to the hyaluronan complexes rather than enabling contact with inflammation-promoting receptors on the underlying tissues. Leukocytes are thus maintained in a non-activated state by appropriate receptor clustering or receptor co-engagement. Additionally, hyaluronan networks might serve as scaffolds to prevent the loss of extracellular matrix components during inflammation and to sequester proinflammatory mediators.