Bacterial DNA segregation by the actin-like MreB protein
Bacterial DNA segregation by the actin-like MreB protein
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DOI：
10.1016/j.tcb.2005.05.002
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发表时间：
2005-07-01
影响因子：
19
通讯作者：
Gerdes, K
中科院分区：
文献类型：
--
作者：
Kruse, T;Gerdes, K
忠实的染色体分离对所有生物都是至关重要的。真核细胞在有丝分裂过程中使用基于微管蛋白的细胞骨架来分离它们的染色体。一些论文已经提供了令人信服的证据，证明在细菌中，这一任务是由肌动蛋白同源物MreB完成的。特别是，Gitai等人最近的一项研究。证明MreB特异性地结合和分离细菌染色体的复制起点。
Faithful chromosome segregation is vital to all organisms. Eukaryotic cells use the tubulin-based cytoskeleton to segregate their chromosomes during mitosis. A handful of papers have provided convincing evidence that, in bacteria, this task is accomplished by the actin homolog MreB. In particular, a recent study by Gitai et al. demonstrates that MreB specifically binds to and segregates the replication origin of the bacterial chromosome.