Spatial order within but not between types of retinal neurons
Spatial order within but not between types of retinal neurons
复制标题
DOI：
10.1073/pnas.030413497
复制
发表时间：
2000-02-29
影响因子：
11.1
通讯作者：
Masland, RH
中科院分区：
文献类型：
--
作者：
Rockhill, RL;Euler, T;Masland, RH
我们研究了六种视网膜神经元的镶嵌结构，询问一个细胞的位置与同一类型的其他细胞的位置以及不同类型的细胞的位置之间的关系。研究发现，每一个神经元的位置都是非随机的：特定类型的细胞是均匀分布的。然而，所有细胞相对于其他细胞类别的成员随机定位。即使在已知细胞是通过突触连接的情况下，情况也是如此。这与发育模式形成的概念是一致的，其中（i）特定类型的细胞数量及其层状分布是特定的，以及（ii）每个细胞的最终空间位置完全由防止相同类型的细胞彼此靠近的规则控制。这种顺序意味着细胞的最终位置是独立的细胞的位置时，其规格，我们提出了一个原因，在层状结构包含许多细胞类型，这可能是可取的。
We studied the mosaics of six types of retinal neurons, asking how the position of a cell relates to the positions of other cells of that same type and also to cells of different types. Every neuron studied was found to be nonrandomly positioned: Cells of a particular type were evenly spaced. However, all cells were positioned randomly with respect to members of the other cell classes. This was true even when the cells were known to be synaptically connected. It is consistent with a concept of developmental pattern formation in which (i) the number of cells of a particular type and their laminar distribution are specified, and (ii) the final spatial position of each cell is controlled exclusively by a rule that prevents cells of the same type from being positioned close to each other. This sequence would imply that a cell's final position is independent of the cell's position at the time of its specification, and we suggest a reason why, in laminar structures containing many cell types, it might be desirable for this to be so.