Risk factors for the development of hip osteoarthritis: a population-based prospective study
Risk factors for the development of hip osteoarthritis: a population-based prospective study
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DOI：
10.1093/rheumatology/ken427
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发表时间：
2009-01-01
期刊：
影响因子：
5.5
通讯作者：
Arokoski, J. P. A.
中科院分区：
文献类型：
--
作者：
Juhakoski, R.;Heliovaara, M.;Arokoski, J. P. A.
目标。潜在的危险因素及其在髋关节骨关节炎病因学中的作用尚不清楚。在一项长达22年的前瞻性研究中，我们分析了几个可能导致髋关节骨性关节炎的危险因素。1978年至1980年，在具有全国代表性的芬兰成年人样本中进行了一项全面的健康调查。在2000-01年度，该调查邀请了1286名参与者进行复试，其中909人同意参加。在排除了基线水平的髋关节骨性关节炎患者和不再工作的患者后，共有840名受试者组成了目前的研究人群。髋关节骨性关节炎的诊断是在标准化临床检查的基础上进行的，医生在基线和复查阶段都采用了统一的标准。随访22年后，41例(4.9%)患者被诊断为髋关节骨性关节炎。重体力劳动可预测髋关节骨性关节炎的风险[调整后的优势比(OR)为6.7；95%可信区间为2.3，19.5]。任何肌肉骨骼损伤导致的永久性损伤也是髋关节骨性关节炎的独立预测因素(调整后的OR5.0；95%可信区间1.9，13.3)。体重指数、吸烟、饮酒和闲暇时间体育活动不是预测髋关节OA的因素。工作中沉重的身体压力和严重的肌肉骨骼损伤与临床诊断为髋关节骨性关节炎的风险增加有关。
Objectives. Potential risk factors and their roles in the aetiology of hip OA are poorly understood. We analysed several alleged risk factors predisposing to hip OA in a 22-yr prospective study.Methods. A comprehensive health survey was carried out in 1978-80 in a nationally representative sample of adult Finns. In 2000-01, 1286 participants in that survey were invited for re-examination, and 909 agreed to participate. After excluding those with hip OA at the baseline and those who were no longer working, a total of 840 subjects constituted the present study population. Hip OA was diagnosed on the basis of a standardized clinical examination by physicians who applied uniform criteria both at the baseline and at the re-examination phase.Results. After 22 yrs of follow-up, hip OA was diagnosed in 41 subjects (4.9%). Heavy manual labour predicted the risk of developing hip OA [adjusted odds ratio (OR) 6.7; 95% CI 2.3, 19.5]. Permanent damage as a consequence of any musculoskeletal injury was also an independent predictor of hip OA (adjusted OR 5.0; 95% CI 1.9, 13.3). BMI, smoking, alcohol intake and leisure time physical activity were not factors which were predictive for hip OA.Conclusion. Heavy physical stress at work and major musculoskeletal injuries are associated with an increased risk of developing clinically diagnosed hip OA.