Pathological implications of cell cycle re-entry in Alzheimer disease.
Pathological implications of cell cycle re-entry in Alzheimer disease.
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DOI：
10.1017/s146239941000150x
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发表时间：
2010-06-29
影响因子：
6.2
通讯作者：
Lee HG
中科院分区：
文献类型：
--
作者：
Bonda DJ;Lee HP;Kudo W;Zhu X;Smith MA;Lee HG
阿尔茨海默病 (AD) 背后的复杂神经变性虽然尚未完全了解，但其特征是神经元异常重新进入细胞周期。细胞周期标记物和调节蛋白形式的病理证据表明，细胞周期折返是 AD 的早期事件，它先于 β 淀粉样斑块和神经原纤维缠结 (NFT) 的形成。尽管在 AD 中诱导和介导这些细胞周期事件的确切机制尚不清楚，但在进一步了解 AD 中细胞周期重新进入的病理作用方面已经取得了重大进展。重要的是，最近的研究表明，细胞周期重新进入不是神经变性的结果，而是原因，这表明细胞周期重新进入的靶向可能为治疗干预提供机会。此外，已经提出了多种细胞周期再进入诱导剂及其在 AD 中的相互作用。在这里，我们回顾了理解 AD 细胞周期重新进入的病理意义的最新进展。
The complex neurodegeneration underlying Alzheimer disease (AD), although incompletely understood, is characterized by an aberrant reentry into the cell cycle in neurons. Pathological evidence, in the form of cell cycle markers and regulatory proteins, suggests that cell cycle reentry is an early event in AD, which precedes the formation of amyloid-β plaques and neurofibrillary tangles (NFTs). Although the exact mechanisms that induce and mediate these cell cycle events in AD are not clear, significant advances have been made in further understanding the pathological role of cell cycle re-entry in AD. Importantly, recent studies indicate that cell cycle re-entry is not a consequence, but rather a cause, of neurodegeneration, suggesting that targeting of cell cycle reentry may provide an opportunity for therapeutic intervention. Moreover, multiple inducers of cell cycle re-entry and their interactions in AD have been proposed. Here, we review the most recent advances in understanding the pathological implications of cell cycle re-entry in AD.