Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission
Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission
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DOI：
10.1016/s0006-8993(98)01144-5
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发表时间：
1999-01-16
期刊：
影响因子：
2.9
通讯作者：
Moore, SD
中科院分区：
文献类型：
--
作者：
Calton, JL;Wilson, WA;Moore, SD
先前的研究表明乙醇对几个脑区中NMDA受体介导的突触传递具有抑制作用。由于杏仁核在介导EtOH的抗焦虑作用中的假定作用，我们在基底外侧杏仁核的电流钳和电压钳条件下检查了EtOH的这种作用。我们发现乙醇减少NMDA受体介导的突触反应。此外，我们发现NMDA受体介导的去极化也可以激活电压依赖性再生电位，这也是敏感的乙醇。该电流的药理学表征与高阈值Ca2+电流一致。该电流也表现出明显的趋势，在撤出EtOH后瞬时增强。(C)1999 Elsevier Science B.V.保留所有权利。
Previous studies have shown inhibitory effects of EtOH on NMDA receptor-mediated synaptic transmission in several brain regions. We examined this effect of EtOH under both current clamp and voltage clamp conditions in the basolateral amygdala because of the putative role of the amygdala in mediating anxiolytic effects of EtOH. We found that EtOH reduced NMDA receptor-mediated synaptic responses. In addition, we found that NMDA receptor-mediated depolarizations could also activate a voltage-dependent regenerative potential which was also sensitive to EtOH. Pharmacological characterization of this current was consistent with a high-threshold Ca2+ current. This current also exhibited a pronounced tendency towards transient enhancement upon withdrawal of EtOH. (C) 1999 Elsevier Science B.V. All rights reserved.