Potentiation of Ca2+ influx through NMDA channels by action potentials: a computer model.
Potentiation of Ca2+ influx through NMDA channels by action potentials: a computer model.
复制标题
动作电位通过 NMDA 通道增强 Ca2 流入：计算机模型。
DOI：
10.1097/00001756-199911260-00045
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发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Lytton,WW
中科院分区：
文献类型：
--
作者：
Neville,KR;Lytton,WW
In pyramidal cells, somatic action potentials can propagate actively back into the apical dendrites and potentiate calcium influx at simultaneously activated glutamatergic synapses, presumably by relieving the voltage-dependent block of NMDA channels. We have used computer simulations to investigate the conditions under which this potentiation will be optimal. We find that a spike with a long duration and limited amplitude (peak of∼− 10 mV) will be most effective. A back-propagating action potential will achieve this form if the dendritic membrane has a low K+ channel density and a modest Na+ channel density (30–70 pS/μm 2, similar to experimentally observed densities). The relative increase in calcium due to the backpropagating spike will be small, however, unless the accumulated calcium is rapidly removed.
