The Social Conditions in the Genesis of Preeclampsia

The Social Conditions in the Genesis of Preeclampsia
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先兆子痫发生的社会条件

DOI:
10.4236/ojepi.2014.43016
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发表时间:
2014
期刊:
Open Journal of Epidemiology
影响因子:
--
通讯作者:
M. Reyes
M. Reyes
中科院分区:
--
文献类型:
--
作者:
J. Salvador;Y. Martínez;J. M. Ramírez;Marisela Aguilar;M. Reyes

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这篇文章强调了子痫前期作为一个全球公共卫生问题的重要性,以及缺乏一个令人满意的模型来解释其起源。与胎盘病理生理学相关的科学进展,使人们对与子痫前期相关的免疫机制有了更深入的了解,并已转化为更好的治疗方案,也得到了强调,尽管迄今为止这些方法无法解释疾病的起源。从一个理论的方法支持的概念有关的社会决定因素的健康,特别是从目前的心理社会流行病学,提出了一种替代的方法,考虑到先兆子痫的起源。该提案基于科学文献以及作者的工作;它以孕妇不利的社会经济和心理社会条件为参考,将这些条件与一系列失败的适应性生物过程联系起来,这些生物过程与身体无效的变稳态反应密切相关,最终决定了疾病的发生。
This article highlights the importance of preeclampsia as a global public health problem and the lack of a satisfactory model to explain its genesis. Scientific advances relevant to the placental pathophysiology, which have resulted in a deeper understanding of the immunological mechanisms associated to preeclampsia and have been translated into better treatment options, are also highlighted, although to date these approaches cannot explain the origin of the disease. From a theoretical approach underpinned by the concepts related to the social determinants of the health, and specifically from current psychosocial epidemiology, an alternative approach that gives account for the genesis of preeclampsia is proposed. The proposal is based in the scientific literature as well as in the work of the authors; it takes as references unfavorable socioeconomic and psychosocial conditions in pregnant women, linking these conditions to a series of failed adaptive biological processes closely related to an ineffective allostatic response by the body, which ultimately determines the occurrence of the disease.
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